Scientist Profile

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Eduardo A. Padlan

Corresponding Member, NAST

Expertise: Biomedical Science

Dr. Eduardo A. Padlan is recognized for his outstanding contributions and accomplishments in Biophysics, specifically the elucidation of the 3-D structure of hemoglobin and antibodies in relation to their evolution and function. His most recent work on " humanized antibodies " has potential applications in the treatment of various diseases including cancer. He has fourteen granted and pending patents on various aspects and uses of antibodies. Dr. Padlan has contributed to the strengthening of S & T in our country in the fields of molecular biology and immunology through the training of researches and teaching several universities during his regular visits to the country.

Affiliation

Adjunct Professor, Marine Science Institute College of Science University of the Philippines, Diliman, Quezon City

Award

    • Balik Scientist Awardee, DOST, 2008

Education

    • John Hopkins University, Ph.D. Biophysics, 1968
    • John Hopkins University, MS Computer Science, 1984
    • University of the Philippines, BS Physics, 1960

Publication

    • Padlan, E., (1994) Anatomy of the antibody molecule (Citations: 292)
    • Molecular Immunology Volume 31, No. 3
    • Couto, J.R., Padlan, E.A., Blank, E.W., Peterson, J.A., Ceriani, R.L., (1994) Humanization of KC4G3, an Anti-Human Carcinoma Antibody
    • Hybridoma Volume 31, No. 3
    • Suguna, K., Padlan, E.A., Bott, R., Boger, J., Parris, K.D., Davies, D.R., (1992) Structures of complexes of rhizopuspepsin with pepstatin and other statine-containing inhibitors
    • Protein Science Volume 31, No. 3
    • Padlan, E.A., (1991) A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties
    • Molecular Immunology - MOL IMMUNOL Volume 28, No. 4-5
    • Chothia, C., Lesk, A.M., Tramontano, A., Levitt, M., Smith-Gill, S.J., Air, G., Sheriff, S., Eduardo A. Padlan, E.A., Davies, D., William Tulip, R., Colman, P.M., Spinelli, S., (1989) Conformation of Immunoglobulin hypervariable regions
    • Nature Volume 342, No. 6252
    • Padlan, E.A., (1989) Structure of an Antibody-Antigen Complex: Crystal Structure of the HyHEL-10 Fab-Lysozyme Complex
    • Proceedings of the National Academy of Sciences-PNAS Volume 86, No. 15
    • Vercelli, D., Helm, B., Marsh, P., Padlan, E.A., Geha, R.S., Gouid, H., (1989) The B-Cell binding site on human immunoglobulin E
    • Nature Volume 338, No. 6217
    • Helm, B., Marsh, P., Vercelli, D., Padlan, E.A., Gould, H., Geha, R., (1988) The mast cell binding site on human immunoglobulin E
    • Nature Volume 338, No. 6217
    • Padlan, E.A., (1988) Model-Building Study of the Combining Sites of Two antibodies to alpha (1rightarrow 6)dextran
    • Proceedings of the National Academy of Science -PNAS Volume 85, No. 18
    • Padlan, E.A., Davies, D.R., (1986) A model of the Fc of immunoglobulin E
    • Molecular Immunology -MOL IMMUNOL Volume 23, No. 10
    • Padlan, E.A., Cohen, G., Davies, D., (1986) Antibody-Fab Assembly: The interface residues between CH1 and CL
    • Molecular Immunology -MOL IMMUNOL Volume 23, No. 9
    • McCartneyfrancis, N., Padlan, E.A., Cohen, G., Mage, R., (1986) Localization of rabbit kappa light chain allotypic determinants
    • Molecular Immunology - MOL IMMUNOL Volume 23, No. 5
    • Padlan, E.A., Cohen, G., Davies, D., (1985) On the specificity of antibody/antigen interactions: Phosphocholine binding to McPC603 and the correlation of three-dimensional structure and sequence data
    • Annales De L'institut Pasteur. Immunologie Volume 136, No. 2
    • E PADLAN, (1985) Quantitation of the immunogenic potential of protein antigens
    • Molecular Immunology - MOL IMMUNOL Volume 22, No. 11
    • S RUDIKOFF, Y SATOW, E PADLAN, D DAVIES, M POTTER, (1981) Kappa chain structure from a crystallized murine Fab?: Role of joining segment in hapten binding
    • Molecular Immunology - MOL IMMUNOL Volume 18, No. 8
    • E PADLAN, (1979) Evaluation of the structural variation among light chain variable domains
    • Molecular Immunology - MOL IMMUNOL Volume 16, No. 5
    • Padlan, E.A., (1977) Structural basis for the specificity of Antibody-antigen reactions and structural mechanisms for the diversifications of antigen-binding specificities
    • Quarterly Reviews of Biophysics - QUART REV BIOPHYS Volume 10, No. 01
    • E. A. Padlan, (1977) Structural Implications of Sequence Variability in Immunoglobulins
    • Proceedings of the National Academy of Science - PNAS Volume 74, No. 6
    • Padlan, E.A., (1976) Structural basis for the specificity of phosphorylcholine-binding immunoglobulins
    • Molecular Immunology - MOL IMMUNOL Volume 13, No. 11
    • E PADLAN, D DAVIES, S RUDIKOFF, M POTTER, (1976) Structural basis for the specificity of phosphorylcholine-binding immunoglobulins
    • Immunochemistry Volume 13, No. 11
    • E. A. Padlan, (1975) Variability of Three-Dimensional Structure in Immunoglobulins
    • Proceedings of the National Academy of Sciences Volume 72, No. 3