Scientist Profile

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Mafel C. Ysrael

Chemistry, Gold Series Award for Research (2008)

Expertise: Biochemistry, Natural Products Chemistry , Pharmacology

Dr. Mafel C. Ysrael is recognized for important Natural products chemistry and their biological properties, i.e. anti-inflammatory, anticancer, smooth muscle modulating activities and metabolic modifying actions Neutraceuticals and functional foods

Affiliation

Associate Professor 3, Research Center of the Natural Sciences, University of Sto. Tomas, España Manila

Association

    • Philippine Society for Biochemistry and Molecular Biology, Board Member
    • Philippine Society for Biochemistry and Molecular Biology, Secretary
    • Philippine Association for the Advancement of Science, Member
    • National Research Council of the Philippines, Member
    • Australian Society for Medical Research, Member
    • Integrated Chemists of the Philippines, Member
    • Philippine-American Academy of Science and Engineering, Member
    • Natural Products Society of the Philippines, Board Member
    • Natural Products Society of the Philippines, Secretary
    • Natural Products Society of the Philippines, President

Employment

    • Faculty of Pharmacy, University of Santo Tomas, Faculty Member, 1977 - present
    • Nuclear Medicine Laboratory University of Santo Tomas, Nuclear Technician, 1974 - 1977
    • UST Research Center for the Natural Sciences, Researcher, 1986 - present
    • Faculty of Pharmacy University of Santo Tomas, Chairman, Biochemistry Department, 2000 - 2006

Award

    • Gold Series Award for Research, Medicine Auditorium, University of Sto. Tomas (UST), 1995 N 21
    • Gold Series Award for Research , UST , 1998 O 13
    • Dangal Awards for Best Dissertation for 1997, Joint UST Administration , 1999 F 25
    • Gold Series Award for Research, UST , 2000 Mr 1
    • Gold Series Award for Research, UST , 2003 F 27
    • Gold Series Award for Research & International Publication Awards , UST , 2005 Mr 16
    • Gold Series Award for Research, UST, 2008 Mr 13

Research

    • The biological activities of the constituents of Ipomea muricata (jacq.) convolvulaceae [Completed]
    • The complete nuclear magnetic resonance (NMR) assignment of the alkaloids of Ipomoea muricata (Jcq.) Convolvulaceae [Completed]
    • The toxicity of the alkaloids of Ipomoea muricata [On-going]
    • Preliminary studies on the chitanase activity from the pitchers of nepenthes alata [Completed]
    • Evaluation of the effect of aqueous extracts from selected philippine plants on induced lipoprotein oxidation In-vitro [Completed]
    • Constituents of Ipomoea muricata and their biological activities [Completed]
    • Anti-methicillin-resistant staphylococcusaureus (MRSA) activity of muricatin IMD-II-13 from Ipomea muricata (L.) Jacq. (Convolvulaceae) [Completed]
    • The In-vitro bioactivity of Ipomoea muricata (tonkin) crude extract against methicillin-resistant staphyllococcus aureus (MRSA) [Completed]
    • Effects of hemigraphis colorata BL. and drypetes monospermus cf. on smooth muscle activity [On-going]
    • An evaluation of the antimicrobial activity of the crude extract of the seeds of ipomoea muricata against selected clinical isolates [On-going]
    • Anti-inflammatory agents from marine organisms [On-going]
    • The antimicrobial potential of IMD II-13 from epomoea muricata L. (Jacq.) convolvulacea [On-going]
    • Evaluation of the effect of aqueous extracts from selected Philippine plants on induced lipoprotein oxidation in-vitro [On-going]
    • The sensitized guinea pig ileum as an alternative model to the rat paw edema for determining anti-inflammatory activity [On-going]
    • Comparative susceptibility of oxacillin-resistant staphylococcus (ORS) to muricatin IMD II-13 [On-going]
    • The antitubercular activity of ipomoea muricata (Tonkin) by microplate alamar blue assay (MABA) [On-going]

Papers Presented

    • Identification of Phenylpropanoids, Phenylpropanoid Glycosides and Phenylethanol Glycoside from I. muricata Jacq. Convolvulaceae, Research Poster Congress in Science and Technology Chiang Cheng Kuo Memorial Hall Central Library
    • The Genus Pandanus: Its Chemcial and Biological Potentials, NAST Annual Meeting PICC
    • Identification of Phenylpropanoids, Phenylpropanoid Glycosides and Phenylethanol Glycoside from I. muricata Jacq. Convolvulaceae, 2nd NPSP Annual Convention, Ateneo de Manila University, Quezon City
    • The Analgesic Activity of the Alkaloids of Ipomoea muricata (Jacq.) Convolvulaceae, FAOBMB 25th Anniversary Symposium Marine Science Institute, UP Diliman
    • The Anti-inflammatory Properties of Mikania cordata (Burn.F.)B.L. Robinson, Dr. Alfredo Santos Lecture Series on Natural Products, UST College of Medicine, Manila
    • Biochemical Assessment of Anti-inflammatory Compounds from Medicinal Plants VI, Asian Symposium On Medicinal Plants and Spices Bandung, Indonesia
    • Biochemical Assessment of Compounds for Anti-inflammatory Activity, 5th Philippine Chemistry Congress, PCARRD Los Banos, Laguna
    • Inhibition of Leukotriene Synthesis in Leukocytes by Scandenolide, 5th Federation of Asian and Oceanian Biochemist (FAOB) Congress Seoul, Korea
    • The Biological Studies on Mikania cordata (Burm.f.) B.L. Robinson, Research Colloquium for the Sciences, UST Graduate School, Audio Visual Room
    • The Chemical and Biological Studies of Mikania cordata (Burm.F.) B.L. Robinson, NAST Annual Meeting, PICC, Manila
    • Chemical and Biological Studies on Casearia trivalvis, Research Colloquium for the Sciences,UST Graduate School, Audio Visual Room
    • The Genus Pandanus: Its Chemcial and Biological Potentials, UST Research Poster Congress Chiang Ching Kuo Memorial Hall, UST
    • The Chemistry of Ipomoea muricata (Jacq.) Convolvulaceae, 6th Asian Chemical Congress and 11th Philippine Chemistry Congress Philippine Village Airport Hotel
    • Isolation of the Antifungal and Other Bioactive Principle from Ipomoea muricata Convolvulaceae , ASOMPS VIII Melaka, Malaysia
    • The Chemical and Biological Studies of Mikania cordata (Burm.F.) B.L. Robinson, ASOMPS VII STTC, UP Diliman
    • Preliminary Phytochemical and Biological Studies of Peperomia pellucida, Research Colloquium for the Sciences UST Graduate School, Audio Visual Room
    • Identification of Phenylpropanoids, Phenylpropanoid Glycosides and Phenylethanol Glycoside from I. muricata Jacq. Convolvulaceae, 13th Philippine Chemistry Congress, Asia World, Puerto Princesa, Palawan
    • The Analgesic Activity of the Alkaloids of Ipomoea muricata (Jacq.) Convolvulaceae , NAST Annual Meeting the Westin Philippine Plaza Manila Hotel
    • A Comparative Study on the Analgesic Activity of the Alkaloids from the Seeds of Ipomoea muricata (Jacq.) Convolvulaceae, Research Colloquium for Science and Technology CME Auditorium
    • A Cytotoxic and Antitubercular Constituent from the Seeds of Ipomoea muricata (Jacq.) Convolvulaceae, 14th Philippine Chemistry Congress Crown Peak Gardens Convention Center Subic Free Port
    • A Comparative Study on the Analgesic Activity of the Alkaloids from the Seeds of Ipomoea muricata (Jacq.) Convolvulaceae, NAST-PHILAM ACADEMY OF SCIENCE AND ENGINEERING Science and Technology Congress STTC, UP Diliman
    • A Comparative Study on the Analgesic Activity of the Alkaloids from the Seeds of Ipomoea muricata (Jacq.) Convolvulaceae, ASOMPS IX Hanoi, Vietnam
    • A Cytotoxic and Antitubercular Constituent from the Seeds of Ipomoea muricata (Jacq.) Convolvulaceae, University Research Week Science and Technology Research Poster Exhibit Main Building Lobby
    • A Cytotoxic and Antitubercular Constituent from the Seeds of Ipomoea muricata (Jacq.) Convolvulaceae, NPSP 3rd Annual Convention De La Salle University
    • The Complete Nuclear Magnetic Resonance (NMR) Analysis of the Alkaloids of Ipomoea muricata (L.) Jacq, Convolvulaceae , 15th Philippine Chemistry Congress Cebu International Convention Center, Cebu City
    • The Complete NMR Assignment of the Alkaloids of Ipomoea muricata (L.) Jacq, Convolvulaceae, 8th Asian Chemical Congress Taipei, Taiwan
    • The Analgesic Activity of the Alkaloids of Ipomoea muricata (Jacq.) Convolvulaceae: A Correlation of In-vivo and In-vitro Studies, The International Symposium on Recent Developments in the Discovery of Biologically Active Natural Products and 4th NPSP Convention Ateneo de Manila University
    • Ipominium, A New Analgesic Alkaloid from Ipomoea Muricata (L.) Jacq. Convolvulaceae, 16th Philippine Chemistry Congress, Manila Hotel
    • The Analgesic Activity of the Alkaloids of Ipomoea muricata (Jacq.) Convolvulaceae: A Correlation of In-vivo and In-vitro Studies, NAST Annual Meeting Manila Hotel
    • The Potentials of Ipominium as an Analgesic Agent, PAASE 19th Annual Meeting and Symposium Shangri-La Hotel, Makati City
    • Making Effective Research Presentation , Seminar for Researchers: Research Publications and Presentations Office of Research and Development, UST Tanghalang Teresita Quirino, UST Graduate School
    • The Potentials of Ipominium as an Analgesic Agent, Research Fortnight 2000 Science and Technology Research Poster Exhibit Main Building Lobby UST
    • The Analgesic Activity of the Alkaloids of Ipomoea muricata (Jacq.) Convolvulaceae: A Correlation of In-vivo and In-vitro Studies, ASOMPS X Dhaka, Bangladesh
    • The Analgesic Activity of the Alkaloids of Ipomoea muricata (Jacq.) Convolvulaceae: A Correlation of In-vivo and In-vitro Studies, PSBMB 27th Annual Convention SEAFDEC, Tigbauan, Iloilo
    • Monitoring of the Bioactive Constituents in Ipomoea muricata Seeds Collected from 1985-2000 by HPTLC, 17th Chemistry Congress Cagayan De Oro City
    • The Analgesic Activity of the Alkaloids of Ipomoea muricata (Jacq.) Convolvulaceae: A Correlation of In-vivo and In- vitro Studies, World Chemistry Congress Brisbane International Convention Center, Brisbane Australia
    • Monitoring of the Bioactive Constituents in Ipomoea muricata Seeds Collected from 1985-2000 by HPTLC, National Academy of Science and Technology Annual Meeting Manila Hotel
    • Monitoring of the Bioactive Constituents in Ipomoea muricata Seeds Collected from 1985-2000 by HPTLC, World Conference on Science and Technology Philippine Association for the Advancement of Science Manila Hotel
    • Basic Researches in Tonkin, Researches in Pharmacy UST TARC Auditorium
    • Preliminary Studies on the Activity of Nepenthes alata Chitinase, UST S & T Poster Exhibit UST TARC
    • 5, 6 Dibromotryptamine from a Philippine Aplysina Sp. Spnge Inhibits Epinephrine Induced Platelet Aggregation, 7th Annual Convention Natural Products Society of the Philippines UNILAB, Mandaluyong City
    • Evaluation of the Effect of Aqueous Extracts from Selected Philippine Plants on Induced Lipoprotein Oxidation In-vitro, 7th Annual Convention Natural Products Society of the Philippines UNILAB,Mandaluyong City
    • Tonkin Herbal Drug: Multidisciplinary Approach Development, 5th Asian Congress on Microcirculation Westin Philippine Plaza
    • Constituents of Ipomoea muricata (Jacq.) Convolvulaceae and their Biological Activities, 9th International Symposium on Natural Product Chemistry Hotel Pearl Continental Karachi
    • Tonkin Drug: Development from Bench to Clinics, 31st PSBMB Annual Convention Bethel Guest House, Dumaguete City
    • Tonkin Drug: Development from Bench to Clinics, 31st PSBMB Annual Convention Bethel Guest House, Dumaguete City
    • Screening of Certain Philippine Plants for their Effects on Ach-induced Contractile Activity of the Guinea Pig Ileum, 31st PSBMB Annual Convention Bethel Guest House, Dumaguete City
    • Screening for Anti-platelet Aggregation Agents from Marine Organisms, 31st PSBMB Annual Convention Bethel Guest House, Dumaguete City
    • Anti-inflammatory Activity of Some Philippine Plants , UST-PAASE Symposium, 2005, TARC Auditorium, RCNS & College of Science Organizers
    • Anti-inflammatory Determination of Selected Philippine Plants Using the Sensitized Guinea Pig Ileum, 25th Annual PAASE Meeting and Symposium Waterfront Cebu City Hotel, Cebu City
    • Bioassays and Other Ways of Adding Value to Natural Products, 25th Annual PAASE Meeting and Symposium (25th APAMS) post Tutorial Lectures University of San Carlos, PAASE - Organizers

Education

    • University of Santo Tomas, España, Manila, B.S. Chemistry, 1972
    • University of Santo Tomas, España, Manila, M.S. Chemistry, 1989
    • University of Santo Tomas, España, Manila, Ph. D. Chemistry, 1997

Publication

    • Santiago-Mendoza J.S., Ysrael, M.C., (2003) Preliminary study on the effect of the unripe fruits of musa paradisiaca Linn. on postprandial blood glucose levels of nondiabetic and streptozotocin-induced diabetic mice
    • Acta Manilana Volume 51
    • Ysrael, M.C., Nonato, M.G., (1999) Biological activities of chemical constituents from Ipomoea muricata (Jacq). convolvulaceae
    • Acta Manilana Volume 47
    • Ysrael, M.C., Croft, K.D., (1990) Inhibition of leukotriene and platelet activating factor synthesis in Leukocytes by the sesquiterpene Lactone scandenolide
    • Planta Medica Volume 56(3)
    • Ysrael, M.C., Santiago, M., Nonato, M.G., (1995) Diuretics studies of five pandanus species
    • Acta Manilana Volume 43
    • Ysrael, M., (2003) Tonkin herbal drug: A multidisciplinary approach to development
    • Clinical Hemorheology and Microcirculation Volume 29, No. 3-4
    • Ysrael, M.C. Chan, A.G. Liu, X.L. Nepomuceno, D.S. Tan, B.C., (2002) Monitoring of the bioactive constituents in Ipomoea muricata seeds collected from 1985-2000 by HPLC
    • Harnessing Science and Technology to Meet the Global Challenge
    • Bernas, G., Bernaldez, A., Ysrael, M.C, () Basic laboratory studies in biochemistry
    • UST Printing Office
    • Solevilla, R.C., Ysrael, M.C. , (1986) A Laboratory Manual for Pharmacology
    • Salesiana Publishing
    • Guevara, B.Q., Recio-Estrada, B., Ysrael, M.C., (1991) Ipomoea muricata (L.) Jacq. (Tonkin) as a Drug Material
    • UST University Press
    • Apostol, J.G., Quentela, A., Ysrael, M.C., Wadsworth, R.M., (2004) Achras zapota L. and Chrysophyllum cainito L. (Sapotaceae) stem bark extracts cause relaxation in rat oartic rings by the nitric oxide pathway
    • Acta Manilana Volume 52
    • Bernas, G., Bernaldez, A., Ysrael, M.C, (1994) Basic Laboratory Studies in Biochemistry
    • UST Printing Office
    • Ysrael, M.C., Croft, K.D., (1988) A biochemical assessment of the anti-inflammatory activity of compounds from Philippine Medicinal Plants
    • Acta Manilana Volume 37
    • Ysrael, M.C., Croft, K.D., (1990) An evaluation of the anti-inflammatory properties of Mikania cordata (Burm.F.) B.L. Robinson
    • Acta Manilana Volume 38
    • Gonzales, R.E., Ysrael, M.C., (2001) The inhibitory activity of Indigofera zollingeriana Linn. and Vitex trifolia Linn. on carrageenan-induced rat paw edema
    • Acta Manilana Volume 49
    • Quentela, A., Apostol, J.G., Ysrael, M.C., Wadsworth, R.M., (2001) A preliminary study on the relaxant effect of the crude extract and fractions of the bark of Chrysophyllum cainito Linn
    • Acta Manilana Volume 49
    • Gonzales, M.S., Buenafe, E.G., Ysrael, M.C., (1993) Biological screening of ten alkaloid-bearing plant
    • Acta Manilana Volume 41
    • Ysrael, M.C., Waterman,P., Nonato, M.G., (1997) Phenylpropanoids, phenylpropanoid glucosides and a phenylethanol diglucoside from Ipomoea muricata Jacq., Convolvulaceae
    • Acta Manilana Volume 45
    • Ysrael, M.C. , (1999) PROSEA Medicinal and Poisonous Plants
    • Backhuys Publishers, Leiden Volume 12, No. 1
    • Ysrael, M.C., Waterman, P.G., Nonato, M.G., (2000) The complete NMR assignment of the alkaloids of Ipomoea muricata (L.) Jacq. Convolvulaceae
    • Kimika Volume 16, No. 1
    • Jasmin, S., Mendoza, Ysrael, M.C., (2001) The glycemic response of fasting non-diabetic and diabetic mice to unripe fruits of Musa paradisiaca Linn.
    • Acta Manilana Volume 49
    • Torres, R.C., Sison, F.M., Ysrael, M.C., (2003) Phytochemical screening and biological studies on the crude methanol extract of Cinnamomum mercadoi, Vidal
    • Philippine Journal of Science Volume 132, No. 1
    • Ysrael, M.C., (2004) A guidebook to plant screening: Phytochemical and biological
    • Research Center for the Natural Sciences

Trainings

    • Biochemical Assessment of Anti-inflammatory Natural Products, 1988 Je - 1988 N, Department of Medicine, Royal Perth Hospital Perth, Western Australia
    • In-vitro Methods of Anti-inflammatory Activity, 1991 My - 1991 Je, UWA, Department of Medicine, Royal Perth Hospital Perth, Western Australia
    • One-year Training Course in Chemistry, 1992 O - 1993 S, University of Strathclyde, Glasgow, Scotland
    • Guinea Pig Ileum Assay, 2000 Ja - 2000 Mr, Department of Pharmacology, University of Strathclyde, Glasgow, Scotland