Sex: Female
Education:
- Master of Public Health, University of the Philippines Manila, 2019
- Doctor of Medicine, Saint Louis University, 2016
- Bachelor of Science in Public Health, University of the Philippines Manila, 2011
Field of Specialization:
Health Policy
Epidemiology
Re-emerging diseases
Emerging diseases
Researches:
Article title: SNPs associated with sulfonylurea resistance among Filipinos diagnosed with type 2 diabetes mellitus.
Authors: Paz-Pacheco E, Nevado JB,... Calpito, KJAC
Publication title: Journal of ASEAN Federation of Endocrine Societies
Abstract:
No abstract
Full text available upon request to the author
Article title: Variants of SLC2A10 may be Linked to Poor Response to Metformin
Authors: Elizabeth Paz-Pacheco, Jose B Nevado, Jr, Eva Maria C Cutiongco-de la Paz, Gabriel V Jasul, Jr, Aimee Yvonne Criselle L Aman, Elizabeth Laurize A Ribaya, Mark David G Francisco, Ma Luz Vicenta V Guanzon, May L Uyking-Naranjo, Ma Cecille S Añonuevo-Cruz, Maria Patricia Deanna D Maningat, Cristina V Jaring, Paulette D Nacpil-Dominguez, Aniza B Pala-Mohamad, Abigail U Canto, John Paul M Quisumbing, Annabelle Marie M Lat, Diane Carla C Bernardo, Noemie Marie M Mansibang, Karell Jo Angelique C Calpito, Vincent Sean D Ribaya, Julius Patrick Y Ferrer, Jessica H Biwang, Jodelyn B Melegrito, Christian Deo T Deguit, Carlos Emmanuel G Panerio
Publication title: Journal of the Endocrine Society 6(8), August 2022
Abstract:
Purpose
A study among Filipinos revealed that only 15% of patients with diabetes achieved glycemic control, and poor response to metformin could be one of the possible reasons. Recent studies demonstrate how genetic variations influence response to metformin. Hence, the present study aimed to determine genetic variants associated with poor response to metformin.
Methods
Using a candidate variant approach, 195 adult Filipino participants with newly diagnosed type 2 diabetes mellitus (T2DM) were enrolled in a case-control study. Genomic DNA from blood samples were collected. Allelic and genotypic associations of variants with poor response to metformin were determined using exact statistical methods.
Results
Several polymorphisms were nominally associated with poor response to metformin (Puncorr < 0.05). The most notable is the association of multiple variants in the SLC2A10 gene—rs2425911, rs3092412, and rs2425904—with common additive genetic mode of inheritance. Other variants that have possible associations with poor drug response include rs340874 (PROX-AS1), rs815815 (CALM2), rs1333049 (CDKN2B-AS1), rs2010963 (VEGFA), rs1535435 and rs9494266 (AHI1), rs11128347 (PDZRN3), rs1805081 (NPC1), and rs13266634 (SLC30A8).
Conclusion
In Filipinos, a trend for the association for several variants was noted, with further observation that several mechanisms may be involved. The results may serve as pilot data for further validation of candidate variants for T2DM pharmacotherapy.
Full text available upon request to the author
Article title: Monitoring Progress on Gender Equality using the Sustainable Development Agenda.
Authors: Khanna A, Calpito KJAC and Shrivastava G.
Publication title: Oxford Handbook of Civil Society Organizations and SDGs
Abstract:
No abstract
Full text available upon request to the author
Article title: Abortion and Stigma: Cross-country evidence from five countries in Asia.
Authors: Shrivastava G, Calpito KJAC and Khanna A.
Publication title: Sexual and Reproductive Health Matters Journal
Abstract:
No abstract
Full text available upon request to the author
Article title: Selected Sociodemographic and Psychosocial Variables Related to Childbirth Setting in a Barangay in Rosario, Cavite.
Authors: Karell Jo Angelique C. Calpito, Charmaine M. Cañizares, Venice Ann Kaye R. Celis, Nover Edward P. Duarte, Ma. Alea Razelle S. Gaela, John Robert C. Medina, Jonathan P. Guevarra, Ernesto R. Gregorio, Jr
Publication title: Acta Medica Philippina 49(3): 2015
Abstract:
No abstract
Full text available upon request to the author
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