Apolinario D. Nazarea

Details

Dr. Apolinario Nazarea finished both his bachelors and masters degree from the University of the Philippines and his doctorate degree from the University of Chicago specializing in theoretical biology and biophysics. He acquired his Post Doctoral degree from the Faculte des Sciences, Free University in Brussels. He was elected as an Academician in 1990 under the Chemical, Mathematical and Physical Sciences Division (CMPSD) for his contributions to the theories on biophysics and recombinant biotechnology including his own conceptual framework on the structure of RNA/DNA probes. With his internationally cited scientific work and theoretical know how, he has laid the foundation for the design of synthetic vaccines on a sounder molecular basis, using Debye-Waller crystallographic data and other biophysical parameters. At the crossroads of the country's technological surge, his role in the development of biophysics and biotechnology is both pivotal and timely.

Sex: Female

Education:

  • University of the Philippines, Diliman, Quezon City, BS S.T/Physics, Chem, 1962
  • University of the Philippines, Diliman, Quezon City, MA Economics, 1968
  • Free University of Brussels, Postdoctoral: Faculte des Sciences, 1971-1973
  • University of the Philippines, Diliman, Quezon City, Magister (M.A.) (Applied Math. Economics), 1968
  • University of Chicago, USA, Ph.D. in Theoretical Biology / Biophysics, 1971 Je

Field of Specialization:

Biophysics, Physical Mapping of Epitopes , Molecular Polysequences Using Fourier Methods, Physical architectonics of DNA/RNA probes, Co-evolutionary dynamics and its theoretical stability, Electric fields and neural dynamics

 Researches:

Nazarea, A.D., Rice, S.A., (1971) Stability theory for non-linear reaction systems
Proceedings, National Academy of Science, USA Volume 68

Nazarea, A.D., (1971) A theory concerning the conditions of non-oscillations of the transcription process
Biophysik Volume 7

Nazarea, A.D., (1972) New constructive theory of stability of complex of nonlinear multicomponent reactive processes
Biophysik Volume 8

Nazarea, A.D., (1973) Consequences of generalized orthogonal splitting of reactive flux of complex reactive processes
Biophysik Volume 9

Nazarea, A.D., (1973) Equivalent classes of reactive processes
Molecular Physics Volume 25

Nazarea, A.D., (1973) Stochastic theory for nonlinear reactive systems
Zeitschr Volume 28A

Nazarea, A.D., (1974) Critical length of transport dominated region for oscillating nonlinear reactions
Proceedings, National Academy of science, USA Volume 71

Nazarea, A.D., Nicolis, G., (1975) Temporal coherence of oscillatory modes of nonlinear reactive processes: Local Theory
Molecular Physics Volume 29

Nazarea, A.D., (1976) Theory of critical focal size for nonlinear reactive systems
Journal of Theoretical Biology Volume 64

Nazarea, A.D., (1978) Spatio-temporal pattern formation on thin layers and membranes: Critical focal size
Proceedings, National Academy of Science, USA Volume 75

Nazarea, A.D., (1978) Electric fields and self coherent patterns and structures in chemical systems:Large scale effects and biological implications
Advances in Chemical Physics Volume 38

Kondepudi, D.K., Nazarea, A.D., (1978) Field induced instabilities in two-component systems: The cell free glycolytic system
Biophysical Chemistry Volume 8

Herschkowitz-Kaufman, M., Nicolis, G., Nazarea, A.D., (1978) Influence of gravity on pattern formation in nonequilibrium systems
Flugwiss Weltraumforsch Volume 2

Nazarea, A.D., (1983) Coding structure analysis and classification of polynucleotide sequences
DNA Volume 2

Nazarea, A.D., Bloch, D.P., Samrau, A.C., (1985) Detection of fundamental modular format common to tRNA and rRNA
Proceedings, National Academy of Science, USA Volume 82

Nazarea, A.D., Nazarea, M., (1987) Protein conformational and epitope markers
Natural and Applied Science Bulletin Volume 39

Nazarea, A.D., Vasco, D.A., Richardson, R.H., (1987) Dynamics and stability in co-evolutionary biological systems
Theoretical Population Biology Volume 3

Nazarea, A.D., (1974) Calculation of analytic expression for product formation in nonlinear reactive system
Report in Center for Statistical Mechanics and Thermodynamics

Nazarea, A.D., (1978) Fluctuation theory as applied to macromolecules in solution as well as electric field effects in complex biological systems
Advances in Chemical Physics Volume 38

Nazarea, A.D., (1983) Models of effect of radiation on the conduction current facilitated by channel proteins in membranes
Bioelectromagnetics

Nazarea, A.D., (1978) Theory of critical focal size in phospolipid membranes
Proceedings, National Academy of Sciences, USA Volume 75

Nazarea, A.D., (1983) Application computer-assisted design of molecular sequences in terms of spectral (Fourier) methods
DNA Volume Vol 2

Nazarea, A.D., (1985) The detection of an invariant length modularity shared by tRNAs and its evolutionary implications
Proceedings, National Academy of Science, USA Volume 82

Nazarea, A.D., (1978) Membrane biophysics: instabilities, bifurcations and fluctuations in chemical systems
Proceedings of the National Academy of Science and Technology (USA)

Nazarea, T.Y., Cobar, M.L.C., Nato, A.Q., Jr., Nazarea, A.D., (2001) Somatic mutation in peripheral blood lymphocytes among Metro Manila residents
Philippine Nuclear Journal Volume 13

Nazarea, A.D., (1976) Intrinsic critical length associated with oscillary reactive processes in complex solutions: Hydrodynamic estimates.
Journal of Theoretical Biology Volume 64:

Nazarea, A.D., (1974) Theory of critical focal size for non-linear reaction systems.
Proc. National Academy of Science (USA) Volume 71

Nazarea, A.D., (2001) A retrospective look at the work of Professor Fred Hoyle in Stellar Nuclear Synthesis
Philippine Nuclear Journal Volume 13

Papers Presented:

  • The Detection of an Invariant Length Modularity Shared by tRNAs and its Evolutionary Implications , National Academy of Science, USA
  • Spectral Diagnostics, Symmetry Mapping of Molecular Polysequences, 7th National Physics Congress
  • Coding Structure Analysis in Polynucleotide Sequences, 3rd Annual Congress on Recombinant DNA Research, Philadelphia
  • Microcomputer Capacity, Bookstrapping and Parallel Processing, Microcomputer in Physics
  • Spectral Signatures of Sequence Transformations in T24/EJ p21(H-ras-1), 30th Anniversary Symposium on Duplex DNA: Molecular Biology Now and Tomorrow, Churchill College, Cambridge University
  • Analysis, Classification and Generation of Molecular Poly-sequences: Experimental Optimization Using Group-theoretical and Spectral Techniques, Special Seminar at GA Technologies, Inc., San Diego, California
  • Computer-assisted Design of Molecular Sequences: Conceptual Considerations, Asia-Pacific Biotechnology Congress, Manila Garden Hotel, Manila, Philippines
  • Beta-kinked Dynamical Modes in DNA as Basis for Sequence-dependent Promoter Interaction, Thursday Seminar, International Rice Research Institute, Los Banos, Laguna
  • Sampling of Current Microcomputer Usage in Instruction and Research in the Philippine Setting: Where and Whither, Regional Conference on Microcomputers in Physics Instruction and Research, University of the Philippines, Diliman, Quezon City
  • Advances in Biophysics, National Institute of Physics, College of Science, University of the Philippines, Diliman
  • Computer-assisted Prediction of Immunodominant Epitope Markers: Use of Protein Antigen Secondary Structure, Molecular Surface and Debye-Waller data, 4rth Amado Clemente Memorial Foundation (ACMF) Lecture
  • Stability Theory for Non-linear Reaction Systems, Proceedings of the National Academy of Science, USA
  • Critical Length of Transport Dominated Region for Oscillating Nonlinear Reactions, Proceedings of the National Academy of Science, USA
  • Spatio-temporal Pattern Formation on Thin Layers and Membranes: Critical Focal Size, Proceedings, National Academy of Science, USA
  • Calculation of Analytic Expression for Product Formation in Nonlinear Reactive System , Report in Center for Statistical Mechanics and Thermodynamics
  • Some Aspects of Timedependent Behavior of Multiple Product Reaction Chains, Report in Center for Statistical Mechanics and Thermodynamics

Awards:

  • Academician, NAST-DOST, 1990
  • Alfred P. Sloan Predoctoral Fellow, University of Chicago, Division of Biological Sciences and Pritzker School of Medicine, 1968-1971
  • Rockefeller Fellow, Graduate School of Arts and Sciences, University of the Philippines, 1964-1967