GOVPH

Sex: Male

Education:

• Georgetown University School of Medicine, Washington DC, USA, Ph.D. Physiology and Biophysics, 1976
• University of Santo Tomas, Manila, Philippines, Doctor of Medicine, 1965

Field of Specialization:

Biophysics, Physiology and Genetics Biophysics and Hypertension, Molecular Physiology, Biochemistry and Molecular and Cellular Biology, Urology, Anatomy, Endocrinology

Researches:

Jose, PA., Sanada, H., Yatabe, J., Midorikawa, S., Hashimoto, S., Watanabe, T., Moore, JH., Ritchie, MD., Williams, SM., Pezzullo, JC., Sasaki, M., Eisner, GM., & Felder, RA., (2006) Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension
Clinical Chemistry Volume 52, No. 3

Jose, PA., Sanada, H., Yatabe, J., Midorikawa, S., Katoh, T., Hashimoto, S., Watanabe, T., Xu, J., Luo, Y., Wang, X., Zeng, C., Armando, I., & Felder, RA., (2006) Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression
Hypertension Volume 47, No. 6

Yan Liu, Jiang Yang, Hongmei Ren, Duofen He, Yu Han, Changqing Yu, Lin Zhou, Annabelle Pascua, Ines Armando, Pedro A. Jose, Chunyu Zeng, (2011) Inhibitory effect of ETB receptor on Na +?K + ATPase activity via extracellular Ca 2+ entry and Ca 2+ release from the endoplasmic reticulum in renal proximal tubule cells
Metal Powder Report Volume 152

Yu, P., Han, W., Villar, V.A.M., Li, H., Arnaldo,F.B., Concepcion,G.P., Felder, R.A., Quinn, M.T., Jose, P.A., (2011) Dopamine D 1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A?protein kinase C cross talk
Molecular Immunology Volume 50, No. 7

Zeng, C., Asico, L.D., Villar, V.A.M., Shi, W., He, D., Liu, Y., Jose, P.A., (2011) Renal D 3 dopamine receptor stimulation induces natriuresis via an ETB endothelin receptor mechanism
Metal Powder Report Volume 152

Yu, P., Han, W., Zhang, Y., Villar, V.A.M.., Li, H., Felder, R., Jose, P.A., (2011) NADPH Oxidase 5 May Play a Role in Human Essential Hypertension
Molecular Immunology Volume 51

Sanada, H., Jones, J.E., Jose, P.A., (2011) Genetics of Salt-Sensitive Hypertension
Williams, S.M., Addy,J.H., Phillips, J.A., Dai, M., Kpodonu, J., Afful, J., Jackson, H., Joseph, K., Eason, F., Murray, M.M., Epperson, P., Aduonum, A., Jose, P.A., (2010) Combination of variations in multiple genes are associated with hypertension

Sanada, H., Jose, P.A., Hazen-Martin, D., Yu,P.Y., Xu, J., Bruns, D.E., Phipps, J., Carey, R.M., Felder, R.A., (2010) Dopamine1 Receptor Coupling Defect in Renal Proximal Tubule Cells in Hypertension

Zeng, C., Asico, L.D., Wang, X., Hopfer, U., Eisner, G.M., Felder, R.A., Pedro A. Jose, P.A., (2010) Angiotensin II Regulation of AT1 and D3 Dopamine Receptors in Renal Proximal Tubule Cells of SHR

Peiying Yu, Laureano D. Asico, Gilbert M. Eisner, Ulrich Hopfer, Robin A. Felder, Pedro A. Jose, (2010) Renal Protein Phosphatase 2A Activity and Spontaneous Hypertension in Rats

Zeng, C., Luo, Y., Asico, L.D., Hopfer, U., Eisner, G.M., Felder, R.A., Jose, P.A., (2010) Perturbation of D1 Dopamine and AT1 Receptor Interaction in Spontaneously Hypertensive Rats

Xiao Xi Li, Martin Bek, Laureano D. Asico, Zhiwei Yang, David K. Grandy, David S. Goldstein, Marcelo Rubinstein, Gilbert M. Eisner, Pedro A. Jose, (2010) Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type2 Knockout Mice

William J. Welch, Tinatin Chabrashvili, Glenn Solis, Yifan Chen, Pritmohinder S. Gill, Shakil Aslam, Xiaoyan Wang, Hong Ji, Kathryn Sandberg, Pedro Jose, Christopher S. Wilcox, (2010) Role of Extracellular Superoxide Dismutase in the Mouse Angiotensin Slow Pressor Response

Chunyu Zeng, Dan Wang, Zhiwei Yang, Zheng Wang, Lareano D. Asico, Christopher S. Wilcox, Gilbert M. Eisner, William J. Welch, Robin A. Felder, Pedro A. Jose, (2010) Dopamine D1 Receptor Augmentation of D3 Receptor Action in Rat Aortic or Mesenteric Vascular Smooth Muscles

Chunyu Zeng, Zheng Wang, Ulrich Hopfer, Laureano D. Asico, Gilbert M. Eisner, Robin A. Felder, Pedro A. Jose, (2010) Rat Strain Effects of AT1 Receptor Activation on D1 Dopamine Receptors in Immortalized Renal Proximal Tubule Cells

Chunyu Zeng, Zhiwei Yang, Zheng Wang, John Jones, Xiaoyan Wang, Joanna Altea, Amy J. Mangrum, Ulrich Hopfer, David R. Sibley, Gilbert M. Eisner, Robin A. Felder, Pedro A. Jose, (2010) Interaction of Angiotensin II Type 1 and D5 Dopamine Receptors in Renal Proximal Tubule Cells

Chunyu Zeng, Dan Wang, Laureano D. Asico, William J. Welch, Christopher S. Wilcox, Ulrich Hopfer, Gilbert M. Eisner, Robin A. Felder, Pedro A. Jose, (2010) Aberrant D1 and D3 Dopamine Receptor Transregulation in Hypertension

Martin J. Bek, Xiaoyan Wang, Laureano D. Asico, John E. Jones, Shaopeng Zheng, XiaoXi Li, Gilbert M. Eisner, David K. Grandy, Robert M. Carey, Patricio Soares-da-Silva, Pedro A. Jose, (2010) Angiotensin-II Type 1 Receptor-Mediated Hypertension in D4 Dopamine Receptor-Deficient Mice

Chunyu Zeng, Yan Liu, Zheng Wang, Duofen He, Lan Huang, Peiying Yu, Shaopeng Zheng, John E. Jones, Laureano D. Asico, Ulrich Hopfer, Gilbert M. Eisner, Robin A. FelderPedro A. Jose, (2010) Activation of D3 Dopamine Receptor Decreases Angiotensin II Type 1 Receptor Expression in Rat Renal Proximal Tubule Cells

Simão, S., Gomes, P., Jose, P.A., Soares-da-Silva, P., (2010) Increased responsiveness to JNK1/2 mediates the enhanced H 2O 2-induced stimulation of Cl ?/HCO 3 ? exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR
Biochemical Pharmacology Volume 80, No. 6

Pinto, V., Pinho, M.J., Jose, P.A.,Soares-da-Silva, P., (2010) Role of H 2O 2 on the kinetics of low-affinity high-capacity Na +-dependent alanine transport in SHR proximal tubular epithelial cells
Biochemical and Biophysical Research and Communication Volume 398, No. 3

John J. Gildea, Xiaoli Wang, Pedro A. Jose, Robin A. Felder, (2010) Differential D1 and D5 Receptor Regulation and Degradation of the Angiotensin Type 1 Receptor
Armando I., Jose, P.A., (2010) Sensing Salt Intake

Z. Yang, X. Huang, H. Jiang, Y. Zhang, H. Liu, C. Qin, G. M. Eisner, P. Jose, L. Rudolph, Z. Ju, (2009) Short Telomers and Prognosis of Hypertension in a Chinese Population
Hypertension Volume 53, No. 4

V. A. M. Villar, J. E. Jones, I. Armando, C. Palmes-Saloma, P. Yu, A. M. Pascua, L. Keever, F. B. Arnaldo, Z. Wang, Y. Luo, R. A. Felder, P. A. Jose, (2009) G Protein-coupled Receptor Kinase 4 (GRK4) Regulates the Phosphorylation and Function of the Dopamine D3 Receptor (Citations: 6)
Journal of Biological Chemistry Volume 284, No. 32

H. Li, W. Han, V. A. M. Villar, L. B. Keever, Q. Lu, U. Hopfer, M. T. Quinn, R. A. Felder, P. A. Jose, P. Yu, (2009) D1Like Receptors Regulate NADPH Oxidase Activity and Subunit Expression in Lipid Raft Microdomains of Renal Proximal Tubule Cells
Hypertension Volume 53, No. 6

Changqing Yu, C., Zhiwei Yang, Z., Hongmei Ren, H., Zhang, Y., Han, Y., Duofen He, D., Quansheng Lu, Q., Wang, X., Wang, X., Yang, C., Asico, L.D., Hopfer, U., Jose, P.A., (2009) D3 Dopamine Receptor Regulation of ETB Receptors in Renal Proximal Tubule Cells from WKY and SHRs
American Journal of Hypertension Volume 22, No. 8

Wang, X., Armando, I., Upadhyay, A.P.,, (2009) The regulation of proximal tubular salt transport in hypertension: an update
Current Opinion in Nephrology and Hypertension Volume 18, No. 5

Chunyu Zeng, Yu Han, Hefei Huang, Changqing Yu, Hongmei Ren, Weibin Shi, Duofen He, Lan Huang, Chengming Yang, Xukai Wang, Lin Zhou, Pedro A Jose, (2009) D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression
Journal of Hypertension Volume 27, No. 5

Gildea, J.J., Israel, J.A., Johnson, A.K., Zhang, J., Jose, P.A., Felder, R.A., (2009) Caveolin-1 and Dopamine-Mediated Internalization of NaKATPase in Human Renal Proximal Tubule Cells
Hypertension Volume 54, No. 5

J. Yatabe, H. Sanada, M. S. Yatabe, S. Hashimoto, M. Yoneda, R. A. Felder, P. A. Jose, T. Watanabe, (2009) Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II
Ajp: Renal Physiology Volume 296, No. 5

W.-Y. Huang, Z.-G. Li, H. Rus, X. Wang, P. A. Jose, S.-Y. Chen, (2009) RGC32 Mediates Transforming Growth Factor -induced Epithelial-Mesenchymal Transition in Human Renal Proximal Tubular Cells
Journal of Bioloogical Chemistry Volume 284, No. 14

Chunyu Zeng, Van Anthony M. Villar, Peiying Yu, Lin Zhou, Pedro A. Jose, (2009) Reactive Oxygen Species and Dopamine Receptor Function in Essential Hypertension
Clinical and Experimental Hypertension Volume 31, No. 2

Yang, J., Cui, Z., He, D., Ren, H., Han, Y., Yu, C., Fu, C., Wang, Z., Yang, C., Wang, X., Zhou, L., Asico, L.D., Jose, P.A., (2009) Insulin Increases D5 Dopamine Receptor Expression and Function in Renal Proximal Tubule Cells From Wistar-Kyoto Rats
American Journal of Hypertension Volume 22, No. 7

C. S. Escano, I. Armando, X. Wang, L. D. Asico, A. Pascua, Y. Yang, Z. Wang, Y.-S. Lau, P. A. Jose, (2009) Renal dopaminergic defect in C57BI/6J mice
American Journal of Physiology-regulatory Integrative and Comparative Physiology Volume 297, No. 6

Yan Liu, Jian Yang, Hongmei Ren, Duofen He, Annabelle Pascua, M Ines Armando, Chengming Yang, Lin Zhou, Robin A Felder, Pedro A Jose, Chunyu Zeng, (2009) Inhibitory effect of ETB receptor on Na+?K+ ATPase activity by extracellular Ca2+ entry and Ca2+ release from the endoplasmic reticulum in renal proximal tubule cells
Hypertension Research

C. Q. YU, W. B. SHI, J. YANG, C. J. FU, D. F. HEN, L. D. ASICO, P. A. JOSE, C. Y. ZENG, (2009) Aberrant regulation of renal dopamine D3 receptor on sodium excretion in salt-loaded Wistar?Kyoto and spontaneously hypertensive rats
International Journal of Cardiology Volume 137

(2009) D3 dopamine receptor regulation of D5 receptor expression and function in renal proximal tubule cells
Metal Powder Report Volume 137

Li, H., Armando, I., Yu, P., Escano, C., Mueller, S.C., Asico, L., Annabelle Pascua, A., Lu, Q., Wang, X., Van Anthony M. Villar, V.A.M., Jones, J.E., Wang, Z., Jose, P.A., (2009) Inhibitory Effect of of D3 dopamine receptor in insulin receptor expression and function in vascular smooth muscle cells
Metal Powder Report Volume 137

Han, W., Li, H., Villar, V.A.M., Pascua, A.M., Dajani, M.I., X. Wang, X., Natarajan, A., Quinn, M.T., Felder, R.A., Jose, P.A., Yu, P., (2008) Lipid Rafts Keep NADPH Oxidase in the Inactive State in Human Proximal Tubule Cells
Hypertension Volume 51, No. 2

R. Pedrosa, V. A. M. Villar, A. M. Pascua, S. Simao, U. Hopfer, P. A. Jose, P. Soares-da-Silva, (2008) H2O2 Stimulation of the Cl/HCO3- Exchanger by Angiotensin II and Angiotensin II Type 1 Receptor Distribution in Membrane Microdomains
Hypertension Volume 51, No. 5

Zeng, C., Asico, L.D., Yu, C., Villar, V.A.M., Shi, W., Luo, Y., Wang, Z., He, D., Liu, Y., Huang, L., Yang, C., Wang, X., Jose, P.A., (2008) Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions
Kidney International Volume 74, No. 6

Vanda Pinto, Maria João Pinho, Ulrich Hopfer, Pedro A. Jose, Patrício Soares-da-Silva, (2008) Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells
Molecular and Cellular Biochemistry Volume 310, No. 1

C. Zeng, V. A. M. Villar, G. M. Eisner, S. M. Williams, R. A. Felder, P. A. Jose, (2008) G Protein-Coupled Receptor Kinase 4: Role in Blood Pressure Regulation
Hypertension Volume 51, No. 6

S Simño, S Fraga, P A Jose, P Soares-da-Silva, (2008) Oxidative stress and ? 1 -adrenoceptor-mediated stimulation of the Cl ? /HCO 3 ? exchanger in immortalized SHR proximal tubular epithelial cells
British Journal of Pharmacology Volume 153, No. 7

Z. Li, C. Yu, Y. Han, H. Ren, W. Shi, C. Fu, D. He, L. Huang, C. Yang, X. Wang, L. Zhou, L. D. AsicoP. A. Jose, (2008) Inhibitory effect of D1-like and D3 dopamine receptors on norepinephrine-induced proliferation in vascular smooth muscle cells
American Journal of Physiology-heart and Circulatory Physiology Volume 294, No. 6

Wang, X., Villar, V.A.M., Armando, I., Eisner, G.M., Felder, R.A., Jose, P.A., (2008) Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice
Pediatric Nephrology Volume 23, No. 12

J. J. Gildea, X. Wang, P. A. Jose, R. A. Felder, (2008) Differential D1 and D5 Receptor Regulation and Degradation of the Angiotensin Type 1 Receptor
Hypertension Volume 51, No. 2

M. J. Pinho, V. Pinto, M. P. Serrao, P. A. Jose, P. Soares-da-Silva, (2007) Underexpression of the Na+-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney
American Journal of Physiology-regulatory Integrative and Comparative Physiology Volume 293, No. 1

Sonia Simño, Rui Pedrosa, Ulrich Hopfer, David B. Mount, Pedro A. Jose, Patrício Soares-da-Silva, (2008) Short-term regulation of the Cl ?/HCO 3 ? exchanger in immortalized SHR proximal tubular epithelial cells
Biochemical Pharmacology Volume 75, No. 11

Hewang Li, Hui-Fang Li, Felder, R.A., Periasamy, A., Jose, P.A., (2008) Rab4 and Rab11 coordinately regulate the recycling of angiotensin II type I receptor as demonstrated by fluorescence resonance energy transfer microscopy
Journal of Biomedical Optics Volume 13, No. 3

Hewang Li, Ines Armando, Peiying Yu, Crisanto Escano, Susette C. Mueller, Laureano Asico, Annabelle Pascua, Quansheng Lu, Xiaoyan Wang, Van Anthony M. Villar, John E. Jones, Zheng WangPedro A. Jose, (2008) Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells
Journal of Clinical Investigation Volume 118, No. 9

Junichi YATABE, Hironobu SANADA, Sanae MIDORIKAWA, Shigeatsu HASHIMOTO, Tsuyoshi WATANABE, Peter M. ANDREWS, Ines ARMANDO, Xiaoyan WANG, Robin A. FELDER, Pedro A. JOSE, (2008) Effects of Decreased Renal Cortical Expression of G Protein-Coupled Receptor Kinase 4 and Angiotensin Type 1 Receptors in Rats
Hypertension Research Volume 31, No. 7

I. Armando, P. A. Jose, (2008) Sensing Salt Intake
Hypertension Volume 53, No. 2

Zeng, C., Armando, I., Luo, Y., Eisner, G.M., Felder, R.A., Jose, P.A., (2007) Dysregulation of Dopamine-dependent Mechanisms as a Determinant of Hypertension: Studies in Dopamine Receptor Knockout Mice

C. Zeng, I. Armando, Y. Luo, G. M. Eisner, R. A. Felder, P. A. Jose, (2007) Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice
American Journal of Physiology-heart and Circulatory Physiology Volume 294, No. 2

Z. Wang, I. Armando, L. D. Asico, C. Escano, X. Wang, Q. Lu, R. A. Felder, C. G. Schnackenberg, D. R. Sibley, G. M. Eisner, P. A. Jose, (2005) The elevated blood pressure of human GRK4 A142V transgenic mice is not associated with increased ROS production
American Journal of Physiology-heart and Circulatory Physiology Volume 292, No. 5

Zeng, C., Wang, Z., Li, H., Asico, L.D., Hopfer, U., Gilbert M. Eisner, G.M., Felder, R.A., Jose, P.A., (2010) D3 Dopamine Receptor Directly Interacts With D1 Dopamine Receptor in Immortalized Renal Proximal Tubule Cells

Minoru Yoneda, Hironobu Sanada, Junichi Yatabe, Sanae Midorikawa, Shigeatsu Hashimoto, Midori Sasaki, Tetsuo Katoh, Tsuyoshi Watanabe, Peter M. Andrews, Pedro A. Jose, Robin A. Felder, (2010) Differential Effects of Angiotensin II Type1 Receptor Antisense Oligonucleotides on Renal Function in Spontaneously Hypertensive Rats

Chunyu Zeng, Ulrich Hopfer, Laureano D. Asico, Gilbert M. Eisner, Robin A. Felder, Pedro A. Jose, (2010) Altered AT1 Receptor Regulation of ETB Receptors in Renal Proximal Tubule Cells of Spontaneously Hypertensive Rats

Jose, P.A., Soares-da-Silva, P., Eisner, G.M., Felder, R.A., (2010) Dopamine and G protein-coupled receptor kinase 4 in the kidney: Role in blood pressure regulation
Wang, X., Luo, Y., Escano, C.S., Yang, Z. Asico, L.D., Li, H., Jones, J.E., Armando, I., Lu, Q., Sibley, D.R., Eisner,G.M., Jose, P.A., (2010) Upregulation of Renal Sodium Transporters in D5 Dopamine Receptor-Deficient Mice

Armando, I., Wang, X., Villar, A.M., Jones, J.E., Asico, L.D., Escano, C., Jose, P.A., (2010) Reactive Oxygen Species-Dependent Hypertension in Dopamine D2 Receptor-Deficient Mice
M. S. Yatabe, J. Yatabe, M. Yoneda, T. Watanabe, M. Otsuki, R. A. Felder, P. A. Jose, H. Sanada, (2010) Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension
American Journal of Clinical Nutrition Volume 92, No. 1

Natarajan, A., Han, G., Chen, S.Y., Yu, P., White, R., Jose, P., (2010) The D5 Dopamine Receptor Mediates Large-Conductance, Calcium and Voltage-Activated Potassium Channel Activation in Human Coronary Artery Smooth Muscle Cells
Journal of Pharmacology and Experimental Therapeutics Volume 332, No. 2

Rex, E.B., Rankin, M.L., Yang, Y., Lu, Q., Gerfen, C.R., Jose, P.A., Sibley, D.R., (2010) Identification of RanBP 9/10 as Interacting Partners for Protein Kinase C / and the D1 Dopamine Receptor: regulation of PKC-mediated receptor phosphorylation
Molecular Pharmacology

Li, H., Han, W., Villar, A.M., Keever, L.B., Lu, Q., Hopfer, U., Quinn, M.T., Felder, A., Jose, P.A., Yu, P., (2010) D1Like Receptors Regulate NADPH Oxidase Activity and Subunit Expression in Lipid Raft Microdomains of Renal Proximal Tubule Cells

Hirohide Yokokawa, Hironobu Sanada, Aya Goto, Tsuyoshi Watanabe, Robin A. Felder, Pedro A. Jose, Gilbert M. Eisner, Seiji Yasumura, (2010) Characteristics of Antihypertensive Medication and Change of Prescription Over 1 Year of Follow Up in Japan: Fukushima Research of Hypertension (FRESH)
American Journal of Hypertension

Z Chunyu, H Huang, H Ren, J Yang, D He, L Asico, P Jose, (2010) D3 Dopamine receptor regulation of D5 receptor expression and function in renal proximal tubule cells:PP.9.348
Journal of Hypertension Volume 28

Chunyu, Z., Huang, H., Han, Y., He, D., Asico, L., Jose, P.A., (2010) Inhibitory Effect of D3 Dopamine receptors on insulin receptor expression and function in vascular smooth muscle cells
Journal of Hypertension Volume 28

F. Li, Z. Luo, W. Huang, Q. Lu, C. S. Wilcox, P. A. Jose, S. Chen, (2007) Response Gene to Complement 32, a Novel Regulator for Transforming Growth Factor-beta-induced Smooth Muscle Differentiation of Neural Crest Cells
Journal of Biological Chemistry Volume 282, No. 14

I. Armando, X. Wang, V. A. M. Villar, J. E. Jones, L. D. Asico, C. Escano, P. A. Jose, (2007) Reactive Oxygen Species-Dependent Hypertension in Dopamine D2 Receptor-Deficient Mice (Citations: 6)
Hypertension Volume 49, No. 3

R. Pedrosa, N. Goncalves, U. Hopfer, P. A. Jose, P. Soares-da-Silva, (2007) Activity and Regulation of Na+-HCO3- Cotransporter in Immortalized Spontaneously Hypertensive Rat and Wistar-Kyoto Rat Proximal Tubular Epithelial Cells
Hypertension Volume 49, No. 5

Pinho, M., Serrao, M., Jose, P.A.,Soares-da-Silva, P., (2007) Overexpression of Non-Functional LAT1/4F2hc in Renal Proximal Tubular Epithelial Cells from the Spontaneous Hypertensive Rat
Cellular Physiology and Biochemistry Volume 20, No. 5

Maria João Pinho, Maria Paula Serrão, Pedro A. José, Patrício Soares-da-Silva, (2007) Organ specific underexpression renal of Na + -dependent B 0 AT1 in the SHR correlates positively with overexpression of NHE3 and salt intake
Molecular and Cellular Biochemistry Volume 306, No. 1

W. J. Welch, T. Chabrashvili, G. Solis, Y. Chen, P. S. Gill, S. Aslam, X. Wang, H. Ji, K. Sandberg, P. Jose, C. S. Wilcox, (2006) Role of Extracellular Superoxide Dismutase in the Mouse Angiotensin Slow Pressor Response
Hypertension Volume 48, No. 5

Felder, R.A., Jose, P.A., (2006) Mechanisms of Disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity
Nature Clinical Practice Nephrology Volume 2, No. 11

K. E. Lohmueller, L. J. C. Wong, M. M. Mauney, L. Jiang, R. A. Felder, P. A. Jose, S. M. Williams, (2006) Patterns of Genetic Variation in the Hypertension Candidate Gene GRK4: Ethnic Variation and Haplotype Structure
Journal of Phycology Volume 70, No. 1

P Yu, L D Asico, Y Luo, P Andrews, G M Eisner, U Hopfer, R A Felder, P A Jose, (2006) D1 dopamine receptor hyperphosphorylation in renal proximal tubules in hypertension
Kidney International Volume 70, No. 6

Sonia Fraga, Yingjin Luo, Pedro Jose, Kambiz Zandi-Nejad, David Mount, Patricio Soares-da-Silva, (2006) Dopamine D 1 -like Receptor-Mediated Inhibition of Cl - /HCO 3 - Exchanger Activity in Rat Intestinal Epithelial IEC6 Cells is Regulated by G Protein-Coupled Receptor Kinase 6 (GRK 6)
Cellular Physiology and Biochemistry Volume 18, No. 6

Zeng, C., Felder, R.A., Pedro A. Jose, P.A., (2006) A New Approach for Treatment of Hypertension: Modifying D1 Dopamine Receptor Function
Cardiovascular & Hematological Agents in Medicinal Chemistry (formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents) Volume 4, No. 4

Zeng, C., Eisner, G.M., Felder, R.A., Jose, P.A., (2006) D3 Dopamine Receptor and Essential Hypertension
Current Hypertension Reviews Volume 2, No. 3

D. Wang, P. Jose, C. S. Wilcox, (2006) beta1 Receptors Protect the Renal Afferent Arteriole of Angiotensin-Infused Rabbits from Norepinephrine-Induced Oxidative Stress
Journal of The American Society of Nephrology Volume 17, No. 12

WILLIAM J WELCH, MARGARIDA MENDONCA, JONATHAN BLAU, ALEX KARBER, KATHRYN DENNEHY, KINJAL PATEL, YUEN-SUM LAO, PEDRO A JOSÉ, CHRISTOPHER S WILCOX, (2005) Antihypertensive response to prolonged tempol in the spontaneously hypertensive rat (Citations: 20)
Kidney International Volume 68, No. 1

CHUNYU ZENG, ZHENG WANG, LAUREANO D ASICO, ULRICH HOPFER, GILBERT M EISNER, ROBIN A FELDER, PEDRO A JOSE, (2005) Aberrant ETB receptor regulation of AT1 receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats
Kidney International Volume 68, No. 2

Zeng, C., Eisner, G.M., Felder, R.A., Jose, P.A., (2005) Dopamine Receptor and Hypertension
Current Medicinal Chemistry Volume 3, No. 1

Zheng Wang, Laureano D. Asico, Viktor Nazarov, Chunyu Zeng, Gilbert M. Eisner, Robin A. Felder, Lee-Jun Wong, Pedro A. Jose, (2005) AT 1 receptors and hypertension in human GRK4 gamma A142V transgenic mice
American Journal of Hypertension Volume 18, No. 5

ANGULO SAN MILLÁN, JUAN JOSE, J. ANTONIO, DIRECCIÓN DE HACIENDA, Servicio de Tributos Directos, MARTINEZ PEREZ, PEDRO JOSE, (2005) Departamento de Hacienda, Finanzas y presupuestos

Gangshi Wang, Shaun A. Owens, Peiying Yu, Lareano D. Asico, Ulrich Hopfer, Pedro A. Jose, Jing Xu, (2005) Endogenous beta-2 adrenergic receptor involved in abnormal proximal tubule sodium reabsorption in SHR
American Journal of Hypertension Volume 18, No. 5

Zhiwei Yang, Laureano D. Asico, Peiying Yu, Zheng Wang, John E. Jones, Robin A. Felder, David R. Sibley, Pedro A. Jose, (2005) Hypertension and PLD2 regulation by D 5 dopamine receptor
American Journal of Hypertension Volume 18, No. 5

Chunyu Zeng, Peiying Yu, Laureano D. Asico, Ulrich Hopfer, Gilbert M. Eisner, Robin A. Felder, Pedro A. Jose, (2005) Interaction of D 1 dopamine and ETB endothelin receptors in renal proximal tubule and vascular smooth muscle
American Journal of Hypertension Volume 18, No. 5

Xiaoyan Wang, Ines Armando, Amy Mangrum, Mark A. Knepper, Pedro A. Jose, (2005) Protein abundance of renal Na transporters in femal mice lacking type1A angiotensin II receptor
American Journal of Hypertension Volume 18, No. 5

Ines Armando, Xiaoyan Wang, John E. Jones, Laureano D. Asico, Pedro A. Jose, (2005) Impaired response to chronic sodium loading in dopamine D 3 receptor deficient mice
American Journal of Hypertension Volume 18, No. 5

John Edward Jones, Pedro A. Jose, (2005) Hypertension in young children and neonates
Current Hypertension Reports Volume 17, No. 6

Scott M. Williams, Marylyn D. Ritchie, John A. Phillips III, Elliot Dawson, Melissa Prince, Elvira Dzhura, Alecia Willis, Amma Semenya, Marshall Summar, Bill C. White, Jonathan H. Addy, John KpodonuPedro A. Jose, (2004) Multilocus Analysis of Hypertension: A Hierarchical Approach
Human Heredity Volume 17, No. 1

Yu, P., Yang, Z., Jones, J.E., Wang, Z., Shaun A. Owens, S.A., Mueller, S.C., Felder, R.A., Jose, P.A., (2004) D1 dopamine receptor signaling involves caveolin-2 in HEK293 cells
Kidney International Volume 66, No. 6

Maria Joao Pinho, Maria Paula Serrao, Pedro Gomes, Ulrich Hopfer, Pedro A. Jose, P. Soares-da-Silva, (2004) Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells

Kidney International Volume 66, No. 1
Rui Pedrosa, Pedro Gomes, Chunyu Zeng, Ulrich Hopfer, Pedro A Jose, Patrício Soares-da-Silva, (2004) Dopamine D 3 receptor-mediated inhibition of Na + /H + exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells
British Journal of Pharmacology Volume 142, No. 8

Jones, J.E., Jose, P.A., (2004) Neonatal blood pressure regulation
Seminars in Perinatology Volume 28, No. 2

Zhiwei Yang, David R. Sibley, Pedro A. Jose, (2004) D5 Dopamine Receptor Knockout Mice and Hypertension
Journal of Receptors and Signal Transduction Volume 24, No. 3

Zhiwei Yang, David R. Sibley, Pedro A. Jose, (2004) D 5 Dopamine Receptor Knockout Mice and Hypertension
Journal of Receptors and Signal Transduction Volume 24, No. 3

Chunyu Zeng, Laureano D. Asico, Shaopeng Zheng, Ulrich Hopfer, Gilbert M. Eisner, Robin A. Felder, Pedro A. Jose, (2004) Role of Ga 12- and Ga 13-protein subunit linkage of D 3 dopamine receptors in the impaired natriuretic effect of d 3 dopamine receptors in SHRS
American Journal of Hypertension Volume 17, No. 5

Yang, Z., Yu, P., Asicol, L.D., Wang, Z., Jones, J.E., David R. Sibley, D.R., Jose P.A., (2004) D 5 dopamine receptor regulation of reactive oxygen species production and blood pressure in mice
American Journal of Hypertension Volume 17, No. 5

Minoru Yoneda, Hironobu Sanada, Junichi Yatabe, Sanae Midorikawa, Shigeatsu Hashimoto, Tsuyoshi Watanabe, Midori Sasaki, Pedro A. Jose, Robin A. Felder, (2004) Differential regulation of blood pressure and renal function by renal at 1 receptors in normotensive and spontaneously hypertensive rats
American Journal of Hypertension Volume 17, No. 5

Chunyu Zeng, Dan Wang, Christopher S. Wilcox, Gilbert M. Eisner, Robin A. Felder, Pedro A. Jose, (2004) Impaired D1 and D3 Dopamine receptor interaction in vascular smooth muscle from SHRS
Cardiovascular Pathology Volume 13, No. 3

Zhiwei Yang, Peiying Yu, Laureano D. Asico, Robin A. Felder, Pedro A. Jose, (2004) Protein Phosphatase 2A B56? During Development in the Spontaneously Hypertensive Rat
Clinical and Experimental Hypertension Volume 26, No. 3

Xiaohong Huang, Zhenyu Ju, Yan Song, Hongye Zhang, Kai Sun, Hongyan Lu, Zhiwei Yang, Pedro A. Jose, Gang Zhou, Meng Wang, Weifeng Wang, Shixian Feng, (2003) Lack of association between the G protein ?3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study
Journal of Molecular Medicine-jmm Volume 81, No. 11

Pedro A. Jose, Gilbert M. Eisner, Robin A. Felder, (2003) Regulation of Blood Pressure by Dopamine Receptors
Nephron Physiology Volume 95, No. 2

Chunyu Zeng, Laureano D. Asico, Gilbert M. Eisner, Ulrich Hopfer, Pedro A. Jose, Robin A. Felder, (2003) D1 dopamine receptor up-regulates and directly interacts with the D3 dopamine receptor in renal proximal tubule cells
American Journal of Hypertension Volume 16, No. 5

Xiaohong Huang, Zhenyu Ju, Yan Song, Hongye Zhang, Kai Sun, Hongyan Lu, Zhiwei Yang, Pedro A. Jose, Gang Zhou, Meng Wang, Weifeng Wang, Shixian Feng, (2003) Lack of association between the G protein ß3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study

Pedro A. Jose, Gilbert M. Eisner, Robin A. Felder, (2002) Dopamine receptor-coupling defect in hypertension (Citations: 20)
Current Hypertension Reports Volume 4, No. 3

Tom R. Hollon, Martin J. Bek, Jean E. Lachowicz, Marjorie A. Ariano, Eva Mezey, Ramesh Ramachandran, Scott R. Wersinger, Patricio Soares-da-Silva, Zhi Fang Liu, Alexander Grinberg, John Drago, W. Scott YoungPedro A. Jose, (2002) Mice Lacking D5 Dopamine Receptors Have Increased Sympathetic Tone and Are Hypertensive

Watanabe, H., Xu, J., Bengra, C., Jose, P.A., Felder, R.A., (2002) Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4
Kidney International Volume 62, No. 3

Chunyu Zeng, Peiying Yu, Laureano D. Asico, Ulrich Hopfer, Gilbert M. Eisner, Pedro A. Jose, (2002) D3 dopamine receptor up-regulates and directly interacts with the D1 dopamine receptor in renal proximal tubule cells
American Journal of Hypertension Volume 15, No. 4

Yuen-Sum Lao, Edith D. Hendley, Robin A. Felder, Pedro A. Jose, (2002) Elevated Renal Cortical calmodulin-dependent protein kinase activity and blood pressure
Clinical and Experimental Hypertension Volume 24, No. 4

Zhiwei Yang, Shaopeng Zheng, Laureano D. Asico, Peiying Yu, Martin Bek, David R. Sibley, Pedro A. Jose, (2002) D5 dopamine regulation of phospholipase d and blood pressure in mice
American Journal of Hypertension Volume 15, No. 4

Hidetsuna Watanabe, Jing Xu, Pedro A. Jose, Robin A. Felder, (2002) Ligand-independent desensitization of the renal D1 receptor in essential hypertension
American Journal of Hypertension Volume 15, No. 4

Martin J. Bek, Shaopeng Zheng, Jing Xu, Ikuyo Yamaguchi, Laureano D. Asico, Xiaoguang Sun, Pedro A. Jose, (2001) Differential expression of adenylyl cyclases in the rat nephron
Kidney International Volume 60, No. 3

Martin Bek, Shaopeng Zheng, Laureano D Asico, David K Grandy, Marcelo Rubinstein, Robert M Carey, Gilbert M Eisner, Pedro A Jose, (2001) D4 dopamine receptor regulates blood pressure via V1 vasopressin and AT1 receptors
American Journal of Hypertension Volume 14, No. 4

Ursula M. D'Souza, Wei Wang, Da-Qing Gao, Seiji Kanda, Gwang Lee, Eunsung Junn, Cheol Kyu Hwang, Pedro A. Jose, M. Maral Mouradian, (2001) Characterization of the 5? flanking region of the rat D3 dopamine receptor gene: The 5' flanking region of the rat D 3 dopamine receptor gene
Journal of Neurochemistry Volume 76, No. 6

Hironobu Watanabe, Jing Xu, Chikh Bengra, Pedro A Jose, Robin A Felder, (2001) Desensitization of renal D1 dopamine receptors by G protein-coupled receptor kinases and endocytosis
American Journal of Hypertension Volume 14, No. 4

Pedro A. Jose, Gilbert M. Eisner, Robin A. Felder, (2000) Renal dopamine and sodium homeostasis
Current Hypertension Reports Volume 2, No. 2

H Sanada, J Xu, H Watanabe, P. A Jose, R. A Felder, (2000) Differential expression and regulation of dopamine-1(d1) and dopamine-5(d-5) receptor function in human kidney
American Journal of Hypertension Volume 13, No. 4

Yuji Aoki, Diego H. Aviles, Pedro A. Jose, (2000) Biphasic effects of dopamine on 86 rubidium uptake in rat renal proximal tubules
Clinical and Experimental Hypertension Volume 22, No. 3

P. Y Yu, U Hopfer, R. A Felder, P. A Jose, (2000) Increased serine-phosphorylation of the D 1 receptor in renal proximal tubule cells in spontaneous hypertension
American Journal of Hypertension Volume 13, No. 4

Joseph R. Pisegna, Nadya I. Tarasova, Jeffrey A. Kopp, Lawrence D. Asico, Xaio X. Li, James Stalter, Christopher J. Michejda, Pedro A. Jose, Stephen A. Wank, (2000) Cholecystokinin type B receptors (CCKBRS) in the rat kidneymediate gastrin-stimulated urinarysodium excretion through inositol phosphate turnover (IP) and inhibition of Na +/K + ATPase
Gastroenterology Volume 118, No. 4

Joseph R Pisegna, Nadya I Tarasova, Jeffrey A Kopp, Lawrence D Asico, Xaio X Li, Christopher J Michejda, Pedro A Jose, Stephen A Wank, (2000) Gastrin released in response to meal stimulation regulates renal sodium excretion through inositol phosphate turnover (IP) and inhibition of Na+ K+ ATPase
Regulatory Peptides Volume 94, No. 1

H Watanabe, M. A Stier, H Sanada, P. A Jose, R. A Felder, (2000) Differential distribution of G-protein-coupled receptor kinase types 2, 3, 4, 5, and 6 in human brain: an immunohistochemical analysis
American Journal of Hypertension Volume 13, No. 4

P. Benstead, P. Josè, C. Joyce, P. M. Wade, (1999) European Wet Grassland: Guidelines for Management and Restoration

H Sanada, P A Jose, J Xu, P-Y Yu, W Wang, L-J Wong, R A Felder, (1999) Activating Homozygous Gene Variants of FJ1 in Essential Hypertension (Citations: 2)
Pediatric Research Volume 45

Xiao Xi Li, Frederick E Albrecht, Pedro A Jose, (1999) G-?? Protein Regulation of NaH Exchanger3 Activity in Rat Renal Proximal Tubules during Development
Pediatric Research Volume 45

J Xu, F E Albrecht, X-X Li, C A Ladines, U Hopfer, P A Jose, (1999) Differential Regulation of NaH Exchanger3 by D1 Receptors and G-??S in Normotensive and Spontaneously Hypertensive Rats
Pediatric Research Volume 45

H. Sanada, P. A. Jose, J. Xu, P. Yu, D. Hazen-Martin, R. M. Carey, R. A. Felder, (1999) Hyperphosphorylation and desensitization of the dopamine D 1 receptor in renal proximal tubules in essential hypertension
American Journal of Hypertension Volume 12, No. 4

Martin J Bek, Laureano D Asico, Ikuyo Yamaguchi, Pedro A Jose, (1999) Differential Expression of Adenylyl Cyclases in the Rat Nephron
Pediatric Research Volume 45

Pedro A. Jose, Gilbert M. Eisner, Robin A. Felder, (1998) Renal Dopamine Receptors in Health and Hypertension
Pharmacology & Therapeutics Volume 80, No. 2
L D Asico, C Ladines, S Fuchs, D Accili, R M Carey, C Semeraro, F Pocchiari, R A Felder, G M Eisner, P A Jose, (1998) Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension
Journal of Clinical Investigation Volume 102, No. 3

Laureano D. Asico, Gilbert M. Eisner, Pedro A. Jose, (1998) Renal Nerves and D 1 Dopamine Receptor-Mediated Natriuresis
Clinical and Experimental Hypertension Volume 28, No. 2

F. E. Albrecht, J. Xu, O. W. Moe, U. Hopfer, W. F. Simonds, J. Orlowski, P. A. Jose, (1998) F009 Regulation of Na +/H + exchanger-3 (NHE-3) by G-protein subunits in renal brush border membranes
American Journal of Hypertension Volume 11, No. 4

J. Xu, F. E. Albrecht, P. A. Jose, (1998) F010 Impaired receptor but not G-protein regulation of Na +/H + exchanger-3 (NHE-3) in proximal tubule membranes of spontaneously hypertensive rats (SHR)
American Journal of Hypertension Volume 11, No. 4

P. Benstead, M. Drake, P. Josè, O. Mountford, C. Newbold, J. Treweek, (1997) The Wet Grassland Guide: Managing Floodplain And Coastal Wet Grasslands For Wildlife

SANG-HYEON LEE, WEI WANG, SHUNSUKE YAJIMA, PEDRO A. JOSE, M. MARAL MOURADIAN, (1997) Tissue-Specific Promoter Usage in the D 1A Dopamine Receptor Gene in Brain and Kidney (Citations: 9) Tissue-Specific Promoter Usage in the D 1A Dopamine Receptor Gene in Brain and Kidney

Jose, P.A., Rankin, M.L., Marinec, P.S., Cabrera, D.M., Wang, Z., & Sibley, D.R., (2006) The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4
Molecular Pharmacology Volume 3

Jose, P.A., Bek, M.J., Wang, X., Asico, L.D., Jones, J.E., Zheng, S., Li, X., Eisner, G.M., Grandy, D.K., Carey, R.M., & Soares-da-Silva, P., (2006) Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice
Hypertension Volume 47, No. 2

Jose, P.A., Chen, S., Crawford, M., Day, R.M., Briones, V.R., Leader, J.E., & Lechleider, R.J., (2006) RhoA modulates Smad signaling during transforming growth factor-beat-induced smooth muscle differentiation
The Journal of Biological Chemistry Volume 3

Jose, PA., & Jones, JE. "Hypertension in young children and neonates." Current Hypertension Reports 7.6 (2005): 454-60.
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Jose, P.A., Zeng, C.Y., Yang, Z.W., Wu, L.J., Asico, L.D., & Felder, R.A., (2005) Hypertension in D3 dopamine receptor deficient mice
Zhonghua Xin Xue Guan Bing Za Zhi 33.12 (2005): Volume 33, No. 12

Jose, P.A., Yang, Z., Asico, L.D., Yu, P., Wang, Z., Jones, J.E., Escano, C.S., Wang, X., Quinn, MT., Sibley, D.R., Romero, G.G., & Felder, R.A, (2006) D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology Volume 290, No. 1

Jose, PA., Sanada, H., Yatabe, J., Midorikawa, S., Katoh, T., Hashimoto, S., Watanabe, T., Xu, J., Luo, Y., Wang, X., Zeng, C., Armando, I., & Felder, RA, () Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression
Hypertension Volume 47, No. 6

Jose, P.A., Sanada, H., Yatabe, J., Midorikawa, S., Hashimoto, S., Watanabe, T., Moore, J.H., Ritchie, M.D., Williams, S.M., Pezzullo, J.C., et al., (2006) Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension
Clinical Chemistry Volume 53, No. 3

Jose, PA., Zeng, C., Wang, Z., Li, H., Yu, P., Zheng, S., Wu, L., Asico, LD., Hopfer, U., Eisner, GM., & Felder, RA., (2006) D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells
Hypertension Volume 47, No. 3

Jose, P.A., Bek, M.J., Wang, X., Asico, L.D., Jones, J.E., Zheng, S., Li, X., Eisner, GM., Grandy, D.K., Carey, R.M., & Soares-da-Silva, P., (2006) Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice
Hypertension Volume 47, No. 2

Jose, P.A., Chen, S., Crawford, M., Day, R.M., Briones, V.R., Leader, J.E., & Lechleider, R.J., (2006) RhoA modulates Smad signaling during transforming growth factor-beat-induced smooth muscle differentiation
The Journal of Biological Chemistry Volume 281, No. 3

Jose, P.A., Yang, Z., Asico, LD., Yu, P., Wang, Z., Jones, JE., Escano, CS., Wang, X., Quinn, MT., Sibley, D.R., Romero, G.G., & Felder, R.A., (2006) D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology Volume 290, No. 1

Jose, P.A., Jones, J.E., (2005) Hypertension in young children and neonates
Current Hypertension Reports Volume 7, No. 6

Jose, PA., Zeng, CY., Yang, ZW., Wu, LJ., Asico, LD., & Felder, RA. "Hypertension in D3 dopamine receptor deficient mice." Zhonghua Xin Xue Guan Bing Za Zhi 33.12 (2005): 1132-6.
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Kaneko, S., Eisner, G.M., Jose, P.A., (1990) Effect of pramipexole, a dopamine-1/dopamine-2 receptor agonist, on sodium excretion and blood pressure in spontaneously hypertensive rats
Journal of Autonomic Pharmacology - J AUTONOM PHARMACOL Volume 10, No. s1