Custer C. Deocaris

Sex: Male

Education:

University of the Philippines, Diliman, Quezon City, BS Molecular Biology and Biotechnology (cum laude), 1993
University of the Philippines, Diliman, Quezon City, MS Molecular Biology and Biotechnology, 2000
The University of Tokyo, Tokyo, Japan, Doctor of Philosophy in Chemistry & Biotechnology, 2006

Field of Specialization:

Genomics and Systems Biology, Sports Neuroscience, Molecular Biogerontology, Molecular and Cell Biology , Sports Biotechnology

Researches:

Deocaris, C.C. Perez, MST. Guttierez, K.V., (2004) Human amnion extract as radioprotector
Philippine Nuclear Journal Volume 14

Deocaris, C.C. Aquino, DDR. Guttierez, K.V., (2001) Protease inhibitors as radioprotectors: a review of "cutting edge" concept in taming radiation-induced cell death execution along the mouse GI tract
Philippine Nuclear Journal

Tocino, A.B. Deocaris, C.C. Mojica, ERE, (2003) A heavy metal biosensor from chicken feathers
Proc., 40th Annual Convention of the Philippine Society of Animal Scince (PSAS), Oct. 23-24, 2003

Mojica, ERE., Micor, JRL. Santos, J.H. Deocaris, C.C., (2004) Preliminary work on the fabrication of a Kappa-carrageenan-peo metal sensor with radiation polymerization
Philippne Nuclear Journal Volume 14

Deocaris, C.C. et al., (2001) Anti ulcer, anti-protozoan, and anti-cancer activities of irradiated k-carrageenan: Some biological effects of irradiated food grade-carrageenan on various gastrointestinal disorders.
Philippne Nuclear Journal Volume 13

Nato, A.Q. Jr. Enriquez, E.B. Ortis A.T. Deocaris, C.C., (2001) Putative bioindicator of 137CS in Perna viridis
Philippine Nuclear Journal Volume 13

Micor, JRL. Mojica, ERESantos, J.H. Deocaris, C.C., (2004) Selective voltametric detection of mercury (II) by a radiation synthesized feather entrapped-hydrogel modified electrode (FEHM-TRDE)
PhilRice Technical Bulletin Volume 13

Bisnar, P.O. Dones, RASA. Serna, PVA. Deocaris, C.C. Guttierez, K.V. Deocaris, C.C., (2006) Radioprotection of intestinal crypt cells by cox-inhibitors.
Philippine Journal of Science Volume 135(2)

Deocaris, C.C., De Guzman, R.R.C., Abilo, R.M.L., Deocaris, C.C., Gutirrez, A.K.O., Cruz, A.C. and Dela Rosa, A.M., (2001) Anti-cancer, anti-protozoan and anti-ulcer activities of irradiated -carrageenan: some biological effects of irradiated food grade-carrageenan on various gastrointestinal disorders
Phil Nuclear J. Volume 13

Deocaris, C.C., Kaul, S. and Wadhwa, R., (2005) Mortalin - a driver on the crossroads of stress, aging and carcinogenesis
Molecular Biology Approach

Deocaaris, C.C., Kaul, S. and Wadha, R., (2008) Mortalin/mtHsp as chaperonotherapeutic agent
Protein Peptide Lett

Deocaris, C.C., Hideaki, S., Yamaguchi, K., Ohiwa, N., Saito, T., Nishijima, T., Kato, M., Tateoka, M., Matsui, T., Okamoto, M. and Fujikawa, T., (2008) Extract from Acanthopanax senticosus Harms(siberian ginseng) activates NTS and SON/PVN in the rat brain
Biosci Biotechnol Biochem

Deocaris, C.C., Kaul, S.C. and Wadhwa, R., (2008) From proliferative to neurological role of an hsp70 stress chaperone, mortalin
Biogerontology

Deocaris, C.C., Widodo, N., Kaul, S. and Wadhwa, R., (2008) Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology
J Transl Med Volume 6

Deocaris, C.C., Takano, S., Priyandoko, D., Kaul, Z., Yaguchi, T., Kraft, D.C., Yamasaki, K., Kaul, S. and Wadhwa, R., (2008) Glycerol stimulates innate chaperoning, proteasomal and stress-resistance functions: implications for geronto-manipulation
Biogerontology

Deocaris, C.C., Widodo, N., Ishii, T., Kaul, S.C. and Wadhwa, R., (2007) Functional significance of minor structural and expression changes in stress chaperone mortalin
Ann N Y Acad Sc Volume 1119

Deocaris, C.C., Kaul, S.C. and Wadhwa, R., (2007) Use of ribozymes in cellular aging research
Methods Mol Biol Volume 371

Timinkul, A., Kato, M., Omori, T., Deocaris, C.C., Ito, A., Kizuka, T., Sakairi, Y., Nishijima, T., Asada, T. and Soya, H., (2008) Enhancing effect of cerebral blood volume by mild exercise in healthy young men: A near-infrared spectroscopy study
Neurosci Res Volume 61(3)

Soya, H., Mukai, H., Deocaris, C.C., Ohiwa, N., Chang, H., Nishijima, T., Fujikawa, T., Togashi, K., Saito, T., (2007) Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: Establishment of a minimum running stress (MRS) rat model
Neurosci Res Volume 58, No. 4

Soya, H., Nakamura, T., Deocaris, C.C., Kimpara, A., Iimura, M., Fujikawa, T., Chang, H., McEwen, B.S. and Nishijima, T., (2007) BDNF induction with mild exercise in the rat hippocampus
Biochem Biophys Res Commun. Volume 358(4)

Widodo, N., Deocaris, C.C., Kaur, K., Hasan, K., Yaguchi, T., Yamasaki, K., Sugihara, T., Ishii, T., Wadhwa, R. and Kaul, S.C., (2007) Stress chaperones, mortalin, and pex19p mediate 5-aza-2' deoxycytidine-induced senescence of cancer cells by DNA methylation-independent pathway
J Gerontol A Biol Sci Med Sci Volume 62(3)

Deocaris, C.C., Widodo, N., Shrestha, B.G., Kaur, K., Ohtaka, M., Yamasaki, K., Kaul, S.C. and Wadhwa, R., (2007) Mortalin sensitizes human cancer cells to MKT-077-induced senescence
Cancer Lett Volume 252(2)

Kaul, S.C., Deocaris, C.C. and Wadhwa, R., (2006) Three faces of mortalin: a housekeeper, guardian and killer
Exp Gerontol. Volume 42(4)

Chang, H., Saito T, Ohiwa, N., Tateoka, M., Deocaris, C.C., Fujikawa, T. and Soya, H., (2006) Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats
Neurosci Res. Volume 57(3)

Deocaris, C.C., Kaul, S.C. and Wadhwa, R., (2006) On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60
Cell Stress Chaperones Volume 11(2)

Deocaris, C.C., Shrestha, B.G., Kraft, D.C., Yamasaki, K., Kaul, S., Rattan, S.G.I. and Wadhwa, R., (2006) Geroprotection by glycerol: insights to its mechanisms and clinical potentials
Ann N Y Acad Sci. Volume 1067

Kraft, D.C., Deocaris, C.C. and Suresh I.S. Rattan, (2006) Pre-incubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts
Annals N Y Acad Sci. Volume 1067

Kraft, D.C., Deocaris, C.C. and Suresh I.S. Rattan, (2006) Proteasome oscillation during mild heat shock in aging human skin fibroblasts
Annals N Y Acad Sci. Volume 1067

Deocaris, C.C., Yamasaki, K., Kaul, S., Taira, K. and Wadhwa, R., (2006) Structural and functional differences between mouse mot-1 and mot-2 proteins that differ in two amino acids
Annals N Y Acad Sci. Volume 1067

Wadhwa, R., Takano, S., Kaur, K., Deocaris, C.C., Pereira-Smith, O.M., Reddel, R. and Kaul, S.C., (2006) Up-regulation of mortalin/mthsp70/grp75 contributes to human carcinogenesis
Int J. Cancer Volume 118(12)

Deocaris, C.C., Taira, K., Kaul, S.C. and Wadhwa, R., (2005) Mimotope-hormesis and mortalin/grp75/mthsp70: A new hypothesis on how infectious disease-associated epitope mimicry may explain low cancer burden in developing nations
FEBS Letters Volume 579(3)

Wadhwa, R., Deocaris, C.C., Widodo, N., Taira, K. and Kaul, S., (2004) Imminent approaches towards molecular interventions in ageing
Mech Ageing Dev. Volume 126(4)

Deocaris, C.C., Kaul, S.C., Taira, K. and Wadhwa, R., (2004) Trendy RNA tools for aging research
J Gerontol A Biol Sci Med Sci Volume 59(8)

Soya, H., Deocaris, C.C., Yamaguchi, K., Ohiwa, N., Saito, T., Nishijima, T., Kato, M., Tateoka, M., Matsui, T., Okamoto, M. and Fujikawa, T., (2008) Extract from Acanthopanax senticosus Harms (siberian ginseng) activates NTS and SON/PVN in the rat brain
Biosci Biotechnol Biochem

Deocaris, C.C., Kaul, S.C. and Wadhwa, R., (2008) From proliferative to neurological role of an hsp70 stress chaperone, mortalin
Biogerontology

Deocaris, C.C., Widodo, N., Kaul, S. and Wadhwa, R., (2008) Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology
J Transl Med Volume 6

Deocaris, C.C., Widodo, N., Ishii, T.,Kaul, S.C. and Wadhwa, R., (2007) Functional significance of minor structural and expression changes in stress chaperone mortalin
Ann N Y Acad Sci Volume 1119

Deocaris, C.C., Kaul, S.C. and Wadhwa, R., (2007) Use of ribozymes in cellular aging research
Methods Mol Biol Volume 371

Soya, H., Mukai, S., Deocaris, C.C., Ohiwa, N., Chang, H., Nishijima, T., Fujikawa, T., Togashi, K. and Saito, T., (2007) Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: Establishment of a minimum running stress (MRS) rat model
Neurosci Res Volume 58(4)

Kaul, S.C., Deocaris, C.C. and Wadhwa, R., (2006) Three faces of mortalin: a housekeeper, guardian and killer
Exp Gerontol. Volume 42(4)

Chang, H., Saito, T., Saito, T., Ohiwa, N., Tateoka, M., Deocaris, C.C., Fujikawa, T. and Soya, H., (2006) Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats
Neurosci Res. Volume 57(3)

Deocaris, C.C., Kaul, S.C. and Wadhwa, R., (2006) On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60
Cell Stress Chaperones Volume 11(2)

Deocaris, C.C., Shrestha, B.G., Kraft, D.C., Yamasaki, K., Kaul, S. Suresh, G.I. Rattan, and Wadhwa, R., (2006) Geroprotection by glycerol: insights to its mechanisms and clinical potentials
Ann N Y Acad Sci. Volume 1067

Kraft, D.C., Deocaris, C.C. and Suresh I.S. Rattan,, (2006) Pre-incubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts
Annals N Y Acad Sci. Volume 1067

Kraft, D.C., Deocaris, C.C. and Suresh I.S. Rattan,, (2006) Proteasome oscillation during mild heat shock in aging human skin fibroblasts
Annals N Y Acad Sci. Volume 1067

Wadhwa, R., Deocaris, C.C., Widodo, N., Taira, K. and Kaul, S., (2004) Imminent approaches towards molecular interventions in ageing
Mech Ageing Dev. Volume 126(4)

Deocaris, C.C., Kaul, S.C., Taira, K. and Wadhwa, R., (2004) Trendy RNA tools for aging research
J Gerontol A Biol Sci Med Sci. Volume 59(8)

Soya, H., Kato, M., Deoaris, C.C., Nishijima, T., Saito, T., Ohiwa, N., Omori, T., Takano, M., Yanagisawa, H., Kizuka, T., Sakairi, Y., Yamashita, F. and Asada, T., (2008) A dance calisthenics program ameliorates cognitive decline in an aging Japanese community: the Tone town model
J Gerontol A Biol Sci Med Sci

Mojica, E.R.E., Tocaino, A.B., Micor, J.R.L. and Deocaris, C.C., (2006) Poultry feather as modifier in a carbon paste electrode for detecting lead ions
Phil J Science Volume 134(1)

Deocaris, C.C., (2008) Hippocampal systems biology of cognitively-improved rats that underwent chronic mild exercise
manuscript in preparation

Mojica, E.R.E., Deocaris, C.C. and Merca, F.E., (2005) A survey of lectin-like activity in Philippine marine invertebrates
Phil J Science Volume 134(2)

Domingo, and Deocaris, C.C., (2005) Some biophysical changes in the chloroplasts of a Dracaena radiation-mutant
Phil J Science Volume 134(2 )

Deocaris, C.C., Abad, L.B., Enriquez, E.P., De Guzman, Z.M., Aliganga, A.A., Tangonan, M.B., Tolentino, M.M. and Ignacio, L.V., (2006) Radiolytic damage to freeze-dried human amniotic membrane
Phil J Science Volume 134(1)

Mojica, E.R.E., Micor, J.R.L. and Deocaris, C.C., (2005) KaCCFEHM-trode, an example of a radiation synthesized metal sensor with a multi composite modifier
J Appl Sci Res. Volume 1(1)

Mojica, E.R.E., Nato, A.Q. Jr., Ambas, Ma.E.T., Feliciano, C.P., Francisco, Ma.L.D.L. and Deocaris, C.C., (2005) Application of gamma radiation as pretreatment method in the production of fermented fish paste
J Applied Sci Res. Volume 1(1)

Deocaris, C.C., Aguinaldo, R.R., Dela Ysla, J.L., Asencion, A.S. and Mojica, E.R.E., (2005) Hypoglycemic activity of irradiated banaba (Lagerstroemia speciosa Linn.) leaves
J Appl Sci Res. Volume 1(1)

Deocaris, C.C., De Castro, Ma. C.P., Oabel, A.T., Co, E.L. and Mojica, E.R.E., (2005) Screening for anti-angiogenic activity in shiitake mushroom (Lentinus edodes Berk) extracts
J Med Sci. Volume 5(1)

Deocaris, C.C., Micor, J.R.L. and Mojica, E.R.E., (2005) Biological activity of bignay [Antidesma bunius (L.) Spreng] crude extract in Artemia salina
J Med Sci. Volume 5(3)

Endriga, Ma.A., Mojica, E.R.E., Merca, F.E., Lacsamana, M.S. and Deocaris, C.C., (2005) Evaluation of some lectins as anti-protozoal agents
J Med Sci. Volume 5(1)

MIcor, J.R.L., Mojica, E.R.E., Leyson, G.P.M., Petrache, C. and Deocaris, C.C., (2004) Preliminary studies on the characterization and toxicity of the cashew nut shell liquid in Pomacea canaliculata and Artemia salina
Asia Life Sci. Volume 12(1-2)

Deocaris, C.C., (2005) Tapping the world wide web for designing vaccines applicable for livestock diseases
Applications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries

Torres-Villanueva, C.A.T., Relucio, J.L.V., Maligalig, A.C.S., Decanay, Ma.E.K., Osorio, R.G. and Deocaris, C.C. , (2005) Complementing nuclear techniques with DNA vaccine technologies for improving animal health
Applications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries

Mojica, E.R.E., Deocaris, C.C. and Endriga, Ma.A., (2005) Essential oils as anti-protozoal agents
Philippine Journal of Crop Science Volume 29(3)

Micor, J.R.L., Mojica, E.R.E., Santos, J.H. and Deocaris, C.C., (2004) Selective voltammetric detection of mercury (II) by a radiation synthesized feather entrapped-hydrogel modified electrode (FEHM-trode)
Philippine Nuclear Journal Volume 14

Mojica, E.R.E., Micor, J.R.L., Santos, J.H. and Deocaris, C.C., (2004) Preliminary work on the fabrication of a alpha-carrageenan-PEO metal sensor with radiation polymerization
Philippine Nuclear Journal Volume 14

Deocaris, C.C., Perez, Ma.S.T. and Gutierrez, K.V., (2004) Human amnion extract as radioprotector
Philippine Nuclear Journal Volume 14

Deocaris, C.C., Deocaris, C.C., Jacinto, S.D. and De Guzman, Z.M., (2003) Radiosensitivity of angiogenic and mitogenic factors in human amniotic membrane
Philippine Journal of Science Volume 132 (2)

Deocaris, C.C., De Vera, A.C., Ellana, M.M. and Asada, C.O., (2003) In vitro gas production tests on irradiated-chicken feathers to estimate its nutritive value for ruminants
Philippine Journal of Science Volume 132 (2)

Deocaris, C.C., Velasco, Ma.C.R., Billiones, E.L.S.J.B. and Nato, A.Q. Jr., (2002) An evolutionary perspective on the possible involvement of plasminogen in the pathology of bovine spongiform encelopathy (BSE)
Phil J Vet Med Anim Sci. Volume 28(2)

Deocaris, C.C., Aquino, D.D.R. and Gutierrez, K.G., (2001) Protease inhibitors as radioprotectors
Phil Nuclear J. Volume 13

Deocaris, C.C., Nato, A.Q. Jr., Enriquez, E.B. and Ortiz, A.T., (2001) Putative bioindicator of Cs-137 in Perna viridis
Phil Nuclear J. Volume 13

Deoaris, C.C., Gregorio, R.L., Chua, Y.M.Y. and Cruz, A.C., (2001) Tumor cell death-inducing protein from buffalo milk
Phil J Vet Anim Sci Volume 27(1)

Deocaris, C.C., Alejandrino, A.L., Asaad, C.O., Alcantara, J.D., Malabayatas, B.G., De Vera, A.C., Ignacio, L.M. and Herrera, M.S., (1999) Constraints on dairy cattle production under smallhold and communal management systems in the Philippines
International J Preventive Vet Medicine Volume 38

Alejandrino, A.L., Asaad, C.O., Malayabatas, B.G., De Vera, A.C., Ignacio, L.M., Deocaris, C.C. and Herrera, M.S., (1996) Farm application of radioimmunoassay technology in dairy cattle management
Phil Technology Journal Volume 21(4)
Deocaris, C.C., Monje, V.D., Santos, A.D. and Cruz, L.J., (1996) Inter-specific molecular comparisons between a newly sequenced conotoxin preproregion from Conus geographus and a known -conotoxin from Conus magus
The Nucleus Volume 32

Deocaris, C.C, (2011 Jl 13-14) Computational Reconstruction And Characterization Of Ancestral Proteins Relevant to Prokaryotic - Eukaryotic Transition 2 billion Years Ago
Transactions of the National Academy of Science and Technology. Abstracts of Papers Volume 33, No. 1

Deocaris, C.C, (2011 Jl 13-14) Taxonomy of Vegetable Oils based on Fatty Acid Composition
Transactions of the National Academy of Science and Technology. Abstracts of Papers Volume 33, No. 1

Deocaris, C.C, (2011 Jl 13-14) Systems Analysis of X-Chromosol miRNAs and Their Genes Using Informatics Tools
Transactions of the National Academy of Science and Technology. Abstracts of Papers Volume 33, No. 1

Papers Presented:

Solving hard computational problems via in silico molecular catalysis, 26th Annual Scientific Meeting of the National Academy of Science and Technology, Manila, Philippines
Marine invertebrates as source of potential anti tumor and antibacterial agents, 8th PCAMRD Southern Luzon Zonal R&D Review
A neural network model for splice-site recognition of human genome sequences, 30th Annual Convention of the Philippine Society for Biochemistry and Molecular Biology, U.P. College of Medicine
Potential antitumor and antibacterial agents from echinoderm extracts, Philippine Council for Health Research & Development (PCHRD)
Anti-tumor protein from buffalo milk, Department of Agriculture
Thermotropic behavior of lipids extracted from irradiated pork meat, Philippine Society for Animal Science (PSAS)
Opportunities in biotechnology for nuclear energy development, International Youth Nuclear Congress, Taejon, Korea
Anti-tumor protein from buffalo milk, Philippine Society for Animal Science (PSAS)
Ameliorated GI syndrome by radioprotectors, GC-2112 and GX-2137, Philippine Association for Laboratory Animal Science (PALAS)
Development and optimization of a rapid in vitro assay for radioprotectors, Department of Science & Technology (DOST)
Improving dairy cattle production in Southern Luzon, DOST
Radioactive DNA sequencing of a conotoxin, PNRI
Radioactive PTT as part of screening protocol for prospecting radiation worker, Daejon, Korea
Nuclear energy in the post-genomic age, Korean Nuclear Society (KNS) Autumn Meeting, Seoul, Korea
The Philippine Nuclear Energy outlook: death and resurrection of a nuclear dream, Korean Nuclear Society (KNS) Autumn Meeting, Seoul, Korea
Winged hyper-mutated epitope mimetics of VP1 (res 135-146): A molecular design for a broad-spectrum, multivalent synthetic vaccines for FMDV, 2nd Asian Buffalo Congress (ABA) Shangri-La Hotel, Makati City, Philippines

Awards:

3rd Place, Outstanding Biomedical Research Award, Philippine Association for Laboratory Animal Science (PALAS), 1996
Certificate of Commendation, Philippine Nuclear Research Institute, 1995 D
Certificate of Commendation, Philippine Nuclear Research Institute, 1996 D
JSPS Post-Doctoral Fellow, Tsukuba University, 2006
JSPS (Short-Term) Visiting Researcher Fellow, Hamamatsu University School of Medicine, Hamamatsu, Japan, 2002
Cancer Society Fellow, Queensland, Australia, 2001
Competent Toastmasters Award, Toastmasters International, 1996
Best Scientific Paper, Philippine Society for Animal Science (PSAS), 2000
International Cancer Fellow, International Union Against Cancer (IUAC), 1998, 2001
Outstanding Oral Paper, International Youth Nuclear Congress (Taejon, Korea), 2002
Best Scientific Paper, Philippine Society for Animal Science (PSAS), 2002
Director's Award for Outstanding Local Publication, Department of Agriculture, 2001
Guest Lecturer during the Round Table Discussion on Bioterrorism, National Defense College of the Philippines, Camp Aguinaldo, Manila, 2001
International Cancer Fellow, International Union Against Cancer (IUAC), 1998, 2001
Poster Finalist, Philippine Council for Health Research & Development (PCHRD), 2003
Second Prize in Bioinformatics Category, 30th Annual Convention of the Philippine Society for Biochemistry and Molecular Biology, 2003
Finalist, Young Investigator Award, 8th PCAMRD Southern Luzon Zonal R&D Review, 2008
First Place, Best Research Paper, 8th PCAMRD Southern Luzon Zonal R&D Review, 2006
Best Poster in the Chemical, Mathematical and Physical Division, 26th Annual Scientific Meeting of the National Academy of Science and Technology, 2004
National Finalist, Outstanding Applied Research Award, Biological Science Division, Department of Science & Technology (DOST), 1995
National Finalist, Outstanding Applied Research Award, Biological Science Division, Department of Science and Technology (DOST), 1995
3rd Place, Atomic Energy Week Technical Poster Competition, Philippine Nuclear Research Institute (PNRI), 1994
DOST-PCASTRD Scholarship, DOST-PCASTRD Scholarship , 1994-1997
College and University Scholar, University of the Philippines, 1994-1997
Balik Scientist Awardee, DOST, 2010