Dr. Edward F. Barroga is recognized for his significant contributions in animal cancer cell research particularly in canine osteosarcoma (bone cancer) which has become a good model for human osteosarcoma. He has shown that with the use of less toxic differentiation including vitamins and their analogues, canine osteosarcoma cells can be programmed to die willfully and could also be initiated to retransform into normal bone cells. He has also established and characterized a new cell line of bone cancer and has described its metastatic behavior in the lungs. His contributions to knowledge of the biology of cancer cells provide essential information that could lead to the development of diagnostic tests and formation of treatment strategies.
- University of the Philippines at Los Baños, College, Laguna, Doctor of Veterinary Medicine (DVM), 1990
- University of the Philippines at Los Baños,, College, Laguna, Master Science in Animal Nutrition, 1995
- Hokkaido University, Sapporo, Japan, Doctor of Philosophy in Veterinary Medicine, 2000
Field of Specialization
Apoptosis induction of neoplastic diseases, Angiogenesis inhibition of neoplast diseases, Establishment and characterization of neoplastic cell lines, Molecular diagnosis of swine diseases, Differentiation therapy of neoplastic diseases, Angiogenesis inhibition of neoplastic diseases, Development of animal cell culture techniques for animal diseases models and application for in vitro, Cancer metastatic models in vitro and in vivo, Veterinary Medicine
Barroga, E.F., Kadosawa, T., Okumura, M., Fujinaga, T., (1999) Establishment and characterization of the growth and pulmonary metastasis of a highly lung metastasizing cell line from canine osteosarcoma in nude mice
Journal of Veterinary Medical Science Volume 61, No. 4
Barroga, E.F. Kadosawa, T. Okumura, M. Fujinaga, T., (1998) Apoptosis induction of POS canine osteosarcoma cells by vitamin D and retinoids.
Journal of Veterinary Medical Science Volume 60, No. (11):
Barroga, E.F. Kadosawa, T. Okumura, M. Fujinaga, T., (1999) Effects of vitamin D and retinoids on the growth and differentiation in vitro in canine osteosarcoma and its clonal cell lines,
Research in Veterinary Science Volume 66
Barroga, E.F. Kadosawa, T. Okumura, M. Fujinaga, T., () Induction of functional differentiation and growth inhibition in vitro canine osteosarcoma 22-oxa-calcitrol, calcitrol and all trans retinoic acid
Journal of Veterinary Medicine (Series A) Volume 46, No. (9):
Barroga, E.F. Kadosawa, T. Okumura, M. Fujinaga, T., (1999) Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of canine osteosarcoma derived-cell line in vivo and its pulmonary metastasis in vivo.
Research in Veterinary Science Volume 68, No. (1):
Barroga, E.F. Kadosawa, T. Okumura, M. Fujinaga, T., (1999) Influence of vitamin D and retinoids on the induction of functional differentiation in vitro of canine osteosarcoma clonal cells.
Veterinary Journal (British Veterinary Journal) Volume 159, No. (20):
Barroga, E.F., (2000) The role of apoptosis in neoplasia and its induction in canine osteosarcoma cells by differentiation inducing vitamins
The Philippine Journal of Veterinary Medicine Volume 37, No. 2
- Outstanding Young Scientist (Veterinary Oncology), National Academy of Science and Technology, 2001