Dr. Aldwin Anterola's research involves studying the biosynthesis of plant constituents that have medicinal or industrial uses. Their work at the Department of Plant Biology, Southern Illinois University employs multidisciplinary techniques in phytochemistry, molecular biology, biochemistry and tissue culture to understand how the production of plant natural products is controlled. Their long-term goal is to be able to systematically manipulate metabolic pathways for increased production of economically important compounds, as well as to generate novel chemical structures (that may have useful properties) from existing natural templates. Research projects include: (1) development of plant bioreactors that serve as metabolic platforms producing specialty chemicals, e.g. drugs, dyes and perfumes; (2) elucidation of pathways leading to the formation of naturally occurring medicinal compounds in plants, such as biflavonoids, diterpenes and eicosanoids; and (3) isolation and identification of secondary metabolites that target the arachidonic acid inflammatory cascade.

Sex: Male

Education

• Washington State University, Washington, U.S.A., Doctor of Philosophy in Plant Physiology, 2001
• University of the Philippines Los Baños, College, Laguna, Bachelor of Science in Agricultural Chemistry (Cum Laude), 1994

Field of Specialization

Plant Physiology, Phytochemistry, Biochemistry, Molecular Biology, Biotechnology, Genome Analysis, Phytohormones, Gibberellins

Researches

Anterola, A., Göbel, C., Hornung, E., Sellhorn, G., Feussner, I., & Grimes, H., (2009) Physcomitrella patens has lipoxygenases for both eicosanoid and octadecanoid pathways
Phytochemistry Volume 7, No. 1

Morrone, D., Chambers, J., Lowry, L., Kim, G., Anterola, A., Bender, K., & Peters, R.J., (2009) Gibberellin biosynthesis in bacteria: Separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum
FEBS Letters Volume 583

Anterola, A., Shanle, E., Mansouri, K., Schuette, S., & Renzaglia, K., (2009) Gibberellin precursor is involved in spore germination in the moss Physcomitrella patens
Planta Volume 229, No. 4

Anterola, A.M., Shanle, E., Perroud, P.F., & Quatrano, R., (2009) Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens
Transgenic Research Volume 18, No. 4

Rensing, S.A., Lang, D., Zimmer, A.D., Terry, A., Salamov, A., Shapiro, H., Nishiyama, T., Perroud, P.F., Lindquist, E.A., Kamisugi, Y., Tanahashi, T., Sakakibara, K., Fujita, T., Oishi, K., Shin-l, T., Kuroki, Y., Toyoda, A., Suzuki, Y., Hashimoto, S., Yamaguchi, K., Sugano, S., Kohara, Y., Fujiyama, A., Anterola, A., Aoki, S., Ashton, N., Barbazuk, W.B., Barker, E., Bennetzen, J.L., Blankenship, R., Cho, S.H., Dutcher, S.K., Estelle, M., Fawcett, J.A., Gundlach, H., Hanada, K., Heyl, A., Hicks, K.A., Hughes, J., Lohr, M., Mayer, K., Melkozernov, A., Murata, T., Nelson, D.R., Pils, B., Prigge, M., Reiss, B., Renner, T., Rombauts, S., Rushton, P.J., Sanderfoot, A., Schween, G., Shiu, S.H., Stueber, K., Theodoulou, F.L., Tu, H., de Peer, Y.V., Verrier, P.J., Waters, E., Wood, A., Yang, L., Cove, D., Cuming, A.C., Hasebe, M., Lucas, S., Mishler, B.D., Reski, R., Grigoriev, I.V., Quatrano, R.S., & Boore, J.L., (2008) The Physcomitrella Genome Reveals Evolutionary Insights into the Conquest of Land by Plants
Science Volume 319, No. 5859

Anterola, A., & Shanle, E., (2008) Genomic insights in moss gibberellin biosynthesis
The Bryologist Volume 111, No. 2

Cho, M.H., Corea, O.R.A., Yang, H., Bedgar, D. L., Laskar, D.D., Anterola, A.M., Moog-Anterola, F.A., Hood, R.L., Kohalmi, S.E., Bernards, M.A., Kang, C., Davin, L.B., & Lewis, N.G., (2007) Phenylalanine Biosynthesis in Arabidopsis thaliana. Identification and characterization of arogenate dehydratases
Journal of Biological Chemistry Volume 282, No. 42

Murphy, K.A., Kuhle, R.A., Fischer, A.M., Anterola, A.M., & Grimes, H.D., (2005) The functional status of paraveinal mesophyll vacuoles changes in response to altered metabolic conditions in soybean leaves
Functional Plant Biology Volume 32, No. 4

Costa, M.A., Collins, R.E., Anterola, A.M., Cochrane, F.C., Davin, L.B., & Lewis, N.G., (2003) An in silico assessment of gene function and organization of the phenylpropanoid pathway metabolic networks in Arabidopsis thaliana and limitations thereof
Phytochemistry Volume 64

Anterola, A.M., & Lewis, N.G., (2002) Trends in Lignin Modification: A Comprehensive Analysis of the Effects of Genetic Manipulations/Mutations on Lignification and Vascular Integrity
Phytochemistry Volume 61, No. 3

Anterola, A.M., Jeon, J.H., Davin, L.B., & Lewis, N.G., (2002) Transcriptional control of monolignol biosynthesis in Pinus taeda: Factors affecting monolignol ratios and carbon allocation in phenylpropanoid metabolism
Journal of Biological Chemistry Volume 277, No. 21

Anterola, A.M., van Rensburg, H., van Heerden, P.S., Davin, L.B., & Lewis, N.G., (1999) Multi-Site Modulation of Flux during Monolignol Formation in Loblolly Pine (Pinus taeda)
Biochemical and Biophysical Research Communications Volume 261, No. 3

Bernards, M.A., Susag, L.M., Bedgar, D.L., Anterola, A.M., & Lewis, N.G., (2000) Induced phenylpropanoid metabolism during suberization and lignification: A comparative analysis
Journal of Plant Physiology Volume 157, No. 6

van Rensburg, H., Anterola, A.M., Levine, L.H., Davin, L.B., & Lewis, N.G., (1999) Chapter 3: Monolignol Compositional Determinants in Loblolly Pine: Aromatic Amino Acid Metabolism and Associated Rate-Limiting Steps

Lignin: Historical, Biological, and Materials Perspectives. ACS Symposium Series Volume 742
Sipes, S.D., Hartz, K.E.H., Amin, H., Anterola, A., & Nickrent, D.L., (2014) Floral scent and pollinators of the holoparasite Pilostyles thurberi (Apodanthaceae)
Journal of Pollination Ecology Volume 12, No. 5

Anterola, A., Ham, R., Perroud, P.F., & Quatrano, R., (2010) Taxane Bryotechnology Production of Anticancer Compounds Using Transgenic Moss
In Vitro Cellular and Developmental Biology - Anilam Volume 46, No. Suppl 

Awards

• Balik Scientist Awardee, DOST, 2009
• Helen and Loyal H. Davis Fellowship, Washington State University
• Student Award for Best Paper, Phytochemical Society of North America
• Graduate Student Award (Cellulose and Paper Division), American Chemical Society